| The effect of omega-3 fatty acid and ascorbic acid on healing of ischemic colon anastomoses. | |
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MedLine Citation:
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PMID: 22229237 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: Many systemic and local factors contribute to gastrointestinal tract anastomoses dehiscence, which is a serious and potentially fatal postoperative complication. The aim of this study was to evaluate the effects of omega-3 fatty acid and ascorbic acid on the healing of ischemic colon anastomosis. PATIENTS AND METHODS: 40 Wistar Albino rats weighing between 180 and 220 g were divided into four groups. Groups were assigned as follows; Group 1 (control): anastomosis and no treatment, Group 2: anastomosis plus ascorbic acid, Group 3: anastomosis plus omega-3 fatty acid, and Group 4: anastomosis plus ascorbic acid and omega-3 fatty acid. Colon anastomoses was were performed in all rats. All animals were sacrificed on the 5th postoperative day. Healing of the anastomoses was assessed by measuring the burst pressures (BP) and hydroxyproline levels. RESULTS: No mortality was observed and perianastomotic abscesses were not noted in any rats. The BP was significantly higher in the ascorbic acid plus omega-3 fatty acid combination group than the other groups (p < 0.05). The hydroxyproline levels were significantly high in ascorbic acid plus omega-3 fatty acid combination group than the other groups (p < 0.05). CONCLUSION: Dietary supplementation with omega-3 fatty acid and ascorbic acid improved colonic anastomoses healing. Ascorbic acid and omega-3 fatty acid enhance the colonic wound healing process by additive action. |
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Authors:
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Baki Ekçi; Ihsan Karabicak; Pinar Atukeren; Ediz Altinlio; Kamer Tomaoglu; Ihsan Tasci |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annali italiani di chirurgia Volume: 82 ISSN: 0003-469X ISO Abbreviation: Ann Ital Chir Publication Date: 2011 Nov-Dec |
Date Detail:
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Created Date: 2012-01-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372343 Medline TA: Ann Ital Chir Country: Italy |
Other Details:
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Languages: eng Pagination: 475-9 Citation Subset: IM |
Affiliation:
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Medical School of Yeditepe University, Department of General Surgery, Istanbul, Turkey. drbaki@yahoo.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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