Document Detail

The effect of oligomycin and some nitrophenols on acid secretion and oxygen uptake by gastric mucosa of the frog.
MedLine Citation:
PMID:  5914259     Owner:  NLM     Status:  MEDLINE    
1. The ability of the three nitrophenols, m-nitrophenol, p-nitrophenol and 2,4-dinitrophenol, to inhibit acid secretion and stimulate oxygen uptake by gastric mucosa paralleled their extent of dissociation at physiological pH.2. Oligomycin inhibited oxygen uptake by gastric mucosa, and showed a tendency to inhibit acid secretion.3. 2,4-dinitrophenol lowered the value of the ratio between acid secretion and the associated oxygen uptake. Oligomycin did not affect the value of this ratio.4. It would appear that a non-phosphorylated high-energy intermediate of oxidative phosphorylation might be involved in acid secretion by gastric mucosa.
W H Bannister
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of physiology     Volume:  186     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1966 Sep 
Date Detail:
Created Date:  1966-12-02     Completed Date:  1966-12-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  89-96     Citation Subset:  IM    
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MeSH Terms
Gastric Juice / drug effects*
Gastric Mucosa / drug effects*,  metabolism*
Nitrophenols / pharmacology*
Oligomycins / pharmacology*
Oxidative Phosphorylation
Oxygen Consumption*
Reg. No./Substance:
0/Nitrophenols; 0/Oligomycins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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