| The effect of olestra on the absorption, excretion and storage of 2,2',5,5' tetrachlorobiphenyl; 3,3',4,4' tetrachlorobiphenyl; and perfluorooctanoic acid. | |
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MedLine Citation:
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PMID: 19616301 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mice were gavaged with either (14)C-labeled 2,2'5,5' tetrachlorobiphenyl; 3,3',4,4' tetrachlorobiphenyl; or perfluorooctanoic acid. Absorption of these compounds was determined by assay of feces collected for 48 h after the gavage. Part of the animals received test diets containing olestra during this 48-hour period to determine its effect on absorption of the compounds. Mice that received the diet without olestra during this period were divided into groups that either continued the diet without olestra or changed to a diet containing olestra. These diets were continued for 7 days, and a second 48-hour fecal collection was made to measure the effect of olestra on enterohepatic circulation of the compounds and their metabolites. The animals were sacrificed, and blood, fat, and liver concentrations of (14)C were measured. Olestra decreased the absorption of 2,2',5,5' tetrachlorobiphenyl. It also reduced tissue and blood concentrations of this compound. Olestra also decreased the absorption of 3,3',4,4' tetrachlorobiphenyl, but it did not alter enterohepatic circulation or tissue concentrations. Olestra significantly increased the excretion of perfluorooctanoic acid in the second 48-hour collection, suggesting an effect on enterohepatic circulation. It did not, however, alter tissue concentrations of perfluorooctanoic acid. These data are consistent with previously observed effects of olestra on the absorption and storage of lipophilic compounds. |
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Authors:
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R J Jandacek; T Rider; E R Keller; P Tso |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-07-17 |
Journal Detail:
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Title: Environment international Volume: 36 ISSN: 1873-6750 ISO Abbreviation: Environ Int Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-01-11 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 7807270 Medline TA: Environ Int Country: Netherlands |
Other Details:
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Languages: eng Pagination: 880-3 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pathology and Laboratory Medicine, University of Cincinnati, 2120 E Galbraith Road, Cincinnati, OH 45237, United States. Ronald.jandacek@uc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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chemistry Animals Blood Chemical Analysis Carbon Radioisotopes / metabolism Diet Environmental Pollutants / metabolism Fatty Acids / metabolism* Feces / chemistry Fluorocarbons / metabolism* Liver / chemistry Male Mice Mice, Inbred C57BL Mutagens / metabolism* Octanoic Acids / metabolism* Polychlorinated Biphenyls / metabolism* Staining and Labeling / methods Sucrose / analogs & derivatives*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 ES014464-03/ES/NIEHS NIH HHS; U01ES/CA 012770/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Environmental Pollutants; 0/Fatty Acids; 0/Fluorocarbons; 0/Mutagens; 0/Octanoic Acids; 0/Polychlorinated Biphenyls; 121854-29-3/sucrose polyester; 32598-13-3/3,4,3',4'-tetrachlorobiphenyl; 335-67-1/perfluorooctanoic acid; 35693-99-3/2,5,2',5'-tetrachlorobiphenyl; 57-50-1/Sucrose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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