Document Detail

The effect of obliterative bronchiolitis on breathing pattern during exercise in recipients of heart-lung transplants.
MedLine Citation:
PMID:  2064118     Owner:  NLM     Status:  MEDLINE    
The more rapid and shallow ventilation pattern seen during exercise in patients with obstructive and/or restrictive lung disease has been attributed by some investigators to the effects of vagal afferents from intrapulmonary receptors. Recipients of heart-lung transplants (HLTR) offer a unique opportunity to test this hypothesis since they have denervated lungs and may develop obliterative bronchiolitis after organ rejection. We thus compared the ventilation responses to incremental bicycle ergometry of five HLTR with relatively normal pulmonary function (HLTR-N) and four with bronchiolitis obliterans (HLTR-O). We compared the slopes of the linear portion of the tidal volume versus inspired minute ventilation relationship of both groups. The rate of rise of tidal volume (VT) (slope of VT versus VI) was greater in HLTR-N (0.31 +/- 0.004) than in HLTR-O (0.023 +/- 0.007) (p less than 0.05). This corresponded to a slower increase in respiratory rate (RR) (slope of RR versus Vl/cm) in HLTR-N (0.055 +/- 0.005) than in HLTR-O (0.083 +/- 0.019) (p less than 0.01). Furthermore, values for VT, inspiratory time (TI), and duty cycle (TI/Ttot) measured during exercise at the VT break point were all significantly lower in the HLTR-O than in HLTR-N. We also evaluated the ability of HLTR with lung disease to regulate their ultimate level of ventilation during maximal exercise.(ABSTRACT TRUNCATED AT 250 WORDS)
F C Sciurba; G R Owens; M H Sanders; J P Costantino; I L Paradis; B P Griffith
Related Documents :
1658898 - The effects of inversed ratio ventilation (irv) on arterial oxygenation during mechanic...
4026048 - Ventilatory muscle function during exercise in air and oxygen in patients with chronic ...
1859068 - Effect of hypercapnia on total pulmonary resistance during wakefulness and during nrem ...
3949168 - Ventricular tachycardia.
24357968 - Dynamic training volume: a construct of both time under tension and volume load.
7811178 - Exercise training and severe caloric restriction: effect on lean body mass in the obese.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  144     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-08-08     Completed Date:  1991-08-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  131-5     Citation Subset:  AIM; IM; S    
Department of Medicine, Presbyterian University Hospital, University of Pittsburgh School of Medicine, Pennsylvania.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bronchiolitis Obliterans / physiopathology*
Forced Expiratory Volume
Functional Residual Capacity
Heart-Lung Transplantation*
Maximal Midexpiratory Flow Rate
Physical Exertion*
Pulmonary Gas Exchange
Tidal Volume
Vital Capacity
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Chronic aminophylline administration. Effect on diaphragm contractility and fatigue resistance in vi...
Next Document:  Hypercapnic and hypoxic ventilatory responses in parents and siblings of children with congenital ce...