Document Detail


The effect of obliterative bronchiolitis on breathing pattern during exercise in recipients of heart-lung transplants.
MedLine Citation:
PMID:  2064118     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The more rapid and shallow ventilation pattern seen during exercise in patients with obstructive and/or restrictive lung disease has been attributed by some investigators to the effects of vagal afferents from intrapulmonary receptors. Recipients of heart-lung transplants (HLTR) offer a unique opportunity to test this hypothesis since they have denervated lungs and may develop obliterative bronchiolitis after organ rejection. We thus compared the ventilation responses to incremental bicycle ergometry of five HLTR with relatively normal pulmonary function (HLTR-N) and four with bronchiolitis obliterans (HLTR-O). We compared the slopes of the linear portion of the tidal volume versus inspired minute ventilation relationship of both groups. The rate of rise of tidal volume (VT) (slope of VT versus VI) was greater in HLTR-N (0.31 +/- 0.004) than in HLTR-O (0.023 +/- 0.007) (p less than 0.05). This corresponded to a slower increase in respiratory rate (RR) (slope of RR versus Vl/cm) in HLTR-N (0.055 +/- 0.005) than in HLTR-O (0.083 +/- 0.019) (p less than 0.01). Furthermore, values for VT, inspiratory time (TI), and duty cycle (TI/Ttot) measured during exercise at the VT break point were all significantly lower in the HLTR-O than in HLTR-N. We also evaluated the ability of HLTR with lung disease to regulate their ultimate level of ventilation during maximal exercise.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
F C Sciurba; G R Owens; M H Sanders; J P Costantino; I L Paradis; B P Griffith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  144     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-08-08     Completed Date:  1991-08-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  131-5     Citation Subset:  AIM; IM; S    
Affiliation:
Department of Medicine, Presbyterian University Hospital, University of Pittsburgh School of Medicine, Pennsylvania.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bronchiolitis Obliterans / physiopathology*
Female
Forced Expiratory Volume
Functional Residual Capacity
Heart-Lung Transplantation*
Humans
Male
Maximal Midexpiratory Flow Rate
Physical Exertion*
Pulmonary Gas Exchange
Respiration*
Tidal Volume
Vital Capacity
Grant Support
ID/Acronym/Agency:
1T32 HL-07563/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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