Document Detail

The effect of nortriptyline in elderly patients with cardiac conduction disease.
MedLine Citation:
PMID:  2298706     Owner:  NLM     Status:  MEDLINE    
Ten depressed, elderly patients with cardiac conduction abnormalities were given therapeutic doses of nortriptyline. Serial ECGs revealed no clinically significant adverse cardiac changes. These data, added to the findings of previous research, suggest that tricyclic antidepressants (TCAs) present little risk in patients with first degree atrioventricular block or hemiblock. Patients with bundle-branch block and bifascicular block are at greater risk of adverse cardiac sequelae but can be treated with TCAs. To maximize safety, the authors recommend monitoring serial ECGs and plasma TCA levels.
J T Dietch; M Fine
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  51     ISSN:  0160-6689     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-14     Completed Date:  1990-03-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  65-7     Citation Subset:  IM    
Department of Psychiatry, University of California--Irvine Medical Center, Orange 92668.
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MeSH Terms
Aged, 80 and over
Antidepressive Agents, Tricyclic / adverse effects,  blood
Arrhythmias, Cardiac / complications,  physiopathology*
Depressive Disorder / complications,  drug therapy*
Dose-Response Relationship, Drug
Heart / drug effects,  physiopathology
Heart Block / complications,  physiopathology
Nortriptyline / adverse effects*,  blood
Risk Factors
Reg. No./Substance:
0/Antidepressive Agents, Tricyclic; 72-69-5/Nortriptyline

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