| The effect of nonreceptor adsorption on the lethal action of colicin E1. | |
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MedLine Citation:
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PMID: 2656296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The survivability of Escherichia coli K12s cells has been studied after treatment with 125I-labeled colicin E1. It has been shown that for low amounts of adsorbed colicin the survivability follows single-hit kinetics. When the number of colicin molecules adsorbed exceeds approx. 50 per cell, deviation from single-hit kinetics occurs towards higher survivability. Colicin E1 adsorbed nonreceptorwise by the cell's surface has been shown to inhibit the lethal action of colicin E1 molecules adsorbed at specific receptors. This fact has been used in accounting for the elevated survivability of cells at high colicin doses. The functional significance of the phenomenon is discussed. |
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Authors:
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S R Malkhosyan; A N Rekesh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: FEBS letters Volume: 248 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1989 May |
Date Detail:
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Created Date: 1989-07-05 Completed Date: 1989-07-05 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 83-6 Citation Subset: IM |
Affiliation:
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Institute of Molecular Genetics, USSR Academy of Sciences, Moscow. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adsorption Cell Membrane / drug effects Cell Membrane Permeability / drug effects Cell Survival / drug effects* Colicins / pharmacology* Escherichia coli / drug effects*, metabolism Kinetics |
| Chemical | |
Reg. No./Substance:
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0/Colicins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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