Document Detail


The effect of nonreceptor adsorption on the lethal action of colicin E1.
MedLine Citation:
PMID:  2656296     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The survivability of Escherichia coli K12s cells has been studied after treatment with 125I-labeled colicin E1. It has been shown that for low amounts of adsorbed colicin the survivability follows single-hit kinetics. When the number of colicin molecules adsorbed exceeds approx. 50 per cell, deviation from single-hit kinetics occurs towards higher survivability. Colicin E1 adsorbed nonreceptorwise by the cell's surface has been shown to inhibit the lethal action of colicin E1 molecules adsorbed at specific receptors. This fact has been used in accounting for the elevated survivability of cells at high colicin doses. The functional significance of the phenomenon is discussed.
Authors:
S R Malkhosyan; A N Rekesh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEBS letters     Volume:  248     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-07-05     Completed Date:  1989-07-05     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  83-6     Citation Subset:  IM    
Affiliation:
Institute of Molecular Genetics, USSR Academy of Sciences, Moscow.
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MeSH Terms
Descriptor/Qualifier:
Adsorption
Cell Membrane / drug effects
Cell Membrane Permeability / drug effects
Cell Survival / drug effects*
Colicins / pharmacology*
Escherichia coli / drug effects*,  metabolism
Kinetics
Chemical
Reg. No./Substance:
0/Colicins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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