Document Detail

The effect of non-steroidal anti-inflammatory drugs on medical abortion with mifepristone and misoprostol at 13-22 weeks gestation.
MedLine Citation:
PMID:  16055455     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the biosynthesis of prostaglandins and concerns have been expressed that they might attenuate the effects of exogenous prostaglandins. This randomized study was conducted to evaluate whether NSAID given during medical abortion with mifepristone/misoprostol in the second trimester has a negative effect on the efficacy of the abortifacient by prolonging the induction-to-abortion interval. METHODS: Seventy-four women were treated with the anti-progesterone mifepristone, followed by repeated doses of misoprostol 36-48 h later. They were randomized to receive a prophylactic pain treatment of either paracetamol and codeine or diclofenac with the first dose of misoprostol. RESULTS: Co-treatment of NSAID with misoprostol did not attenuate the efficacy of mifepristone and misoprostol. There was no significant difference between the NSAID and the non-NSAID group in the induction-to-abortion interval (5.4 versus 6.5 h) or the total doses of misoprostol needed (2 versus 3). The frequency of surgical intervention was similar (55.6 versus 52.6%). Women in the group treated with NSAID required significantly less opiates (P = 0.042). CONCLUSION: Co-treatment with NSAID and misoprostol does not interfere with the action of mifepristone and/or misoprostol to induce uterine contractions and pregnancy expulsion in medical abortion. Prophylactic NSAID administration reduces the need for opiate injections.
C Fiala; M L Swahn; O Stephansson; K Gemzell-Danielsson
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2005-07-29
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  20     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-25     Completed Date:  2006-01-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  3072-7     Citation Subset:  IM    
Department of Woman and Child Health, Division for Obstetrics and Gynaecology, Clinical Epidemiology Unit, Karolinska Institute, 171 76 Stockholm, Sweden.
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MeSH Terms
Abdominal Pain / prevention & control
Abortifacient Agents, Nonsteroidal
Abortion, Induced / methods*
Acetaminophen / therapeutic use*
Administration, Intravaginal
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Codeine / analogs & derivatives,  therapeutic use
Diclofenac / therapeutic use*
Drug Therapy, Combination
Gestational Age
Misoprostol* / administration & dosage
Pregnancy Trimester, Second*
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 0/Anti-Inflammatory Agents, Non-Steroidal; 103-90-2/Acetaminophen; 125-28-0/dihydrocodeine; 15307-86-5/Diclofenac; 59122-46-2/Misoprostol; 76-57-3/Codeine; 84371-65-3/Mifepristone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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