| The effect of nitrous oxide on intra-ocular pressure in healthy adults. | |
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MedLine Citation:
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PMID: 22321081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many anaesthetic agents affect intra-ocular pressure, yet little is known about nitrous oxide and intra-ocular pressure. This study assessed the effect of nitrous oxide on intra-ocular pressure in 20 healthy adult volunteers. The intra-ocular pressure was measured at baseline, while breathing a 70:30 mix of nitrous oxide and oxygen for 12 min, and then while breathing room air for 15 min. A linear mixed effects model was used to assess change in intra-ocular pressure over time. There was no significant difference in intra-ocular pressure between baseline and during or after nitrous oxide inhalation. Several differences in intra-ocular pressure were noted between internal time-points: pressure increased by 2.4 mmHg between 3 and 6 min of breathing nitrous oxide (p=0.01); it increased by 1.4 mmHg between 3 and 9 min of breathing nitrous oxide (p=0.046); and it decreased by 2.2 mmHg between 6 min of breathing nitrous oxide and 15 min of breathing room air (p=0.035). This study indicates that nitrous oxide inhalation does not significantly change intra-ocular pressure from baseline values in a population of healthy adults. |
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Authors:
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K Lalwani; E B Fox; R Fu; B Edmunds; L D Kelly |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anaesthesia Volume: 67 ISSN: 1365-2044 ISO Abbreviation: Anaesthesia Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-10 Completed Date: 2012-03-26 Revised Date: 2012-06-19 |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 256-60 Citation Subset: AIM; IM |
Copyright Information:
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Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland. |
Affiliation:
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Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA. lalwanik@ohsu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anesthetics, Inhalation / pharmacology* Female Humans Intraocular Pressure / drug effects* Male Nitrous Oxide / pharmacology* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 10024-97-2/Nitrous Oxide |
| Comments/Corrections | |
Comment In:
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Anaesthesia. 2012 Jun;67(6):680-1
[PMID:
22563970
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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