Document Detail

The effect of nitrous oxide on halothane, isoflurane and sevoflurane requirements in ventilated dogs undergoing ovariohysterectomy.
MedLine Citation:
PMID:  17083606     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the effect of 64% nitrous oxide (N2O) on halothane (HAL), isoflurane (ISO) or sevoflurane (SEV) requirements in dogs undergoing ovariohysterectomy. STUDY DESIGN: Prospective, randomized, clinical trial. ANIMALS: Ninety, healthy dogs of (mean +/- SD) body weight 21.2 +/- 10.0 kg and age 17.8 +/- 22.8 months. MATERIALS AND METHODS: After premedication with acepromazine, hydromorphone and glycopyrrolate, anesthesia was induced with thiopental administered to effect. Dogs received one of six inhalant protocols (n = 15 group): HAL; HAL/N2O; ISO; ISO/N2O; SEV; or SEV/N2O. End-tidal CO2 was maintained at 40 +/- 2 mmHg with intermittent positive pressure ventilation (IPPV). Body temperature, heart rate, indirect systemic arterial blood pressures, inspired and end-tidal CO2, volatile agent, N2O and O2 were recorded every 5 minutes. The vaporizer setting was decreased in 0.25-0.5% decrements to elicit a palpebral reflex, and this level maintained. Statistical analysis included two-way anova for repeated measures with Bonferroni's correction factor and statistical significance assumed when p < 0.05. Percentage reduction in end-tidal volatile agent was calculated at 60 minutes after starting study. RESULTS: End-tidal HAL, ISO and SEV decreased when N2O was administered. Percentage reduction: HAL (12.4%); ISO (37.1%) and SEV (21.4%). Diastolic, mean and systolic blood pressures increased in ISO/N2O compared with ISO. Heart rate increased in ISO/N2O and SEV/N2O compared with ISO and SEV, respectively. Systolic, mean and diastolic blood pressures increased in SEV compared with HAL and ISO. Systolic, mean, diastolic blood pressures and heart rate increased in SEV/N2O and ISO/N2O compared with HAL/N2O. CONCLUSIONS: N2O reduces HAL, ISO and SEV requirements in dogs undergoing ovariohysterectomy. Cardiovascular stimulation occurred when N2O was used with ISO, less so with SEV and not with HAL
T Duke; N A Caulkett; J M Tataryn
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Veterinary anaesthesia and analgesia     Volume:  33     ISSN:  1467-2987     ISO Abbreviation:  Vet Anaesth Analg     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-06     Completed Date:  2006-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956422     Medline TA:  Vet Anaesth Analg     Country:  England    
Other Details:
Languages:  eng     Pagination:  343-50     Citation Subset:  IM    
Department Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
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MeSH Terms
Anesthesia, Inhalation / veterinary*
Anesthetics, Inhalation / administration & dosage,  pharmacology*
Blood Gas Analysis / veterinary
Dogs / physiology*
Drug Therapy, Combination
Halothane / administration & dosage,  pharmacology
Hysterectomy / veterinary
Isoflurane / administration & dosage,  pharmacology
Lung / drug effects*
Methyl Ethers / administration & dosage,  pharmacology
Nitrous Oxide / administration & dosage,  pharmacology*
Prospective Studies
Respiration / drug effects
Treatment Outcome
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 10024-97-2/Nitrous Oxide; 151-67-7/Halothane; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane
Comment In:
Vet Anaesth Analg. 2006 Nov;33(6):341-2   [PMID:  17083605 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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