Document Detail

The effect of nitroglycerin ointment on exercise-induced angina: a multicenter trial.
MedLine Citation:
PMID:  2518679     Owner:  NLM     Status:  MEDLINE    
The efficacy of nitroglycerin ointment was determined by treadmill exercise testing through a randomized, double-blind crossover trial with placebo in 22 patients with chronic stable exertional angina. On different days, 3 cm of nitroglycerin ointment (NGO, 18 mg) and placebo ointment were applied over the epigastric region, followed by the exercise test 1 hour later. The maximal exercise time was 459 +/- 124 seconds after application of placebo and 510 +/- 113 seconds after application of NGO, and the exercise time to 1 mm of ST-segment depression was significantly extended to 297 +/- 110 seconds after placebo and 366 +/- 134 seconds after NGO (p less than 0.01, p less than 0.001, respectively). ST-segment depression at the endpoint of exercise was significantly reduced from 2.4 +/- 1.2 mm to 1.5 +/- 0.7 mm after application of NGO (p less than 0.01). There was no difference in rate-pressure product at the endpoint of exercise between placebo and NGO. Adverse reactions were elicited in 5 of 22 patients. The results of this present study suggest that NGO is effective in the treatment of exertional angina.
H Kishida; Y Inagaki; H Hayakawa; A Kurita; T Saito; H Kitagawa
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  2     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1991-04-23     Completed Date:  1991-04-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  831-6     Citation Subset:  IM    
First Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
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MeSH Terms
Angina Pectoris / drug therapy*,  etiology
Middle Aged
Nitroglycerin / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Ointments; 55-63-0/Nitroglycerin

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