Document Detail

The effect of nifedipine on oral contraceptive-induced hypertension in rats.
MedLine Citation:
PMID:  17203115     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Administration of oral contraceptive (OC) steroids is associated with an increased risk of developing hypertension, although the mechanisms underlying this effect are not well established. This study therefore sought to investigate the effect of L-type calcium channel blocker, nifedipine on OC-induced hypertension. METHODS: Female Sprague-Dawley rats received OC (norgestrel/ethinyloestradiol) and/or nifedipine orally for 10 weeks. . Blood pressure and heart rate were thereafter recorded under anaesthesia from the femoral artery with a Grass Polygraph 7D model, whereas plasma and urinary Na+ and K+ concentrations were measured using a flame photometer. The stable oxidation products of nitric oxide, urinary nitrite/nitrate (NO) were measured in urine by means of the brucine method. RESULTS: OC administration led to significant (p<0.05) increases in blood pressure and plasma Na+, and decreases in body weight, food and water consumption, excretion of Na+ and NO. Concomitant treatment with nifedipine significantly (p<0.05) abrogated the alterations induced by OC administration. CONCLUSION: This study provides evidence that the development of OC-induced hypertension is prevented by calcium channel blockade via improved renal handling of sodium and nitric oxide. The finding confirms the involvement of calcium channels in OC hypertension.
L A Olatunji; A O Soladoye
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Nigerian postgraduate medical journal     Volume:  13     ISSN:  1117-1936     ISO Abbreviation:  Niger Postgrad Med J     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-01-04     Completed Date:  2007-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9613595     Medline TA:  Niger Postgrad Med J     Country:  Nigeria    
Other Details:
Languages:  eng     Pagination:  277-81     Citation Subset:  IM    
Department of Physiology and Biochemistry, College of Medicine, University of Ilorin, Ilorin, Nigeria.
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MeSH Terms
Blood Pressure / drug effects
Calcium Channel Blockers / pharmacology*,  therapeutic use
Ethinyl Estradiol / adverse effects
Hypertension / chemically induced,  drug therapy,  physiopathology*
Natriuresis / drug effects
Nifedipine / pharmacology*,  therapeutic use
Norgestrel / adverse effects
Rats, Sprague-Dawley
Reg. No./Substance:
0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 57-63-6/Ethinyl Estradiol; 6533-00-2/Norgestrel

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