Document Detail

The effect of nicotine on pulmonary epithelial permeability in man.
MedLine Citation:
PMID:  6734296     Owner:  NLM     Status:  MEDLINE    
We examined the effect of nicotine on pulmonary epithelial permeability in man. Nicotine was administered from a chewing gum base given over a seven-day period. An index of pulmonary permeability was derived from the rate of clearance from the lung into the blood of 99mTcDTPA (diethylenetriamine pentacetate). In five nonsmoking volunteers there was no change in permeability for the seven-day study period. This lack of effect of nicotine alone was in striking contrast to the increase in epithelial permeability observed in five nonsmoking subjects who took up cigarette smoking.
B D Minty; D Royston; J G Jones; G H Hulands
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  86     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-08-03     Completed Date:  1984-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  72-4     Citation Subset:  AIM; IM    
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MeSH Terms
Capillary Permeability / drug effects*
Chewing Gum
Middle Aged
Nicotine / blood,  pharmacology*
Reg. No./Substance:
0/Chewing Gum; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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