| The effect of neuropeptides on the release of neurotransmitter amino acids from rat striatum. | |
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MedLine Citation:
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PMID: 7512699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuropeptide Y (NPY), peptide YY (PYY), and galanin are found throughout the central nervous system with appreciable levels occurring in the striatum. In this study we have investigated the effects of these peptides on the potassium-stimulated release of endogenous neurotransmitter amino acids from slices of rat striatum. The release of glutamate was significantly reduced by nanomolar concentrations of each peptide, whilst the release of aspartate, gamma-aminobutyric acid (GABA) and glycine was not affected. The reduction in release due to galanin (200 nM) was inhibited by glibenclamide (5 microM). These results support the view that NPY, PYY and galanin modulate neurotransmitter release possibly by a presynaptic action. The results with glibenclamide suggest that the action of galanin is mediated through an ATP-sensitive potassium channel. |
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Authors:
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Y Ellis; J A Davies |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuropeptides Volume: 26 ISSN: 0143-4179 ISO Abbreviation: Neuropeptides Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-05-18 Completed Date: 1994-05-18 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8103156 Medline TA: Neuropeptides Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 65-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Therapeutics, University of Wales College of Medicine, Cardiff, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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pharmacology Animals Aspartic Acid / secretion* Corpus Striatum / drug effects*, secretion Female Galanin Glyburide / pharmacology* Glycine / secretion* Neurons / secretion Neuropeptide Y / pharmacology* Peptide YY Peptides / pharmacology* Potassium / pharmacology Potassium Channels / drug effects, physiology Rats Rats, Wistar gamma-Aminobutyric Acid / secretion* |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y; 0/Peptides; 0/Potassium Channels; 10238-21-8/Glyburide; 106388-42-5/Peptide YY; 56-12-2/gamma-Aminobutyric Acid; 56-40-6/Glycine; 56-65-5/Adenosine Triphosphate; 56-84-8/Aspartic Acid; 7440-09-7/Potassium; 88813-36-9/Galanin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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