Document Detail

The effect of neonatal oil administration on brain weight of inbred and heterogeneous mice.
MedLine Citation:
PMID:  689297     Owner:  NLM     Status:  MEDLINE    
A single injection of sesame oil on postnatal Day 4 reduced adult bain weight in male and female mice of the C3H/HeJ strain. The same neonatal treatment had no effect on brain weight of heterogeneous mice derived from a cross of 8 inbred strains. In agreement with previous findings in inbred strains, C3H/HeJ females were found to have larger brains than males. This difference between the genders was not seen in heterogeneous mice. The effect of neonatal oil administration on adult brain weight provides an additional example of the effect of neonatal manipulations on the adult organism and underscores the importance of adherence to appropriate control procedures in studies involving administration of hormones in early life, particularly when infant strains are used as experimental subjects.
D A Blizard
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental psychobiology     Volume:  11     ISSN:  0012-1630     ISO Abbreviation:  Dev Psychobiol     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1978-11-27     Completed Date:  1978-11-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  487-93     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn / growth & development
Body Weight / drug effects
Brain / drug effects,  growth & development*
Mice, Inbred C3H
Mice, Inbred Strains
Oils / pharmacology*
Organ Size / drug effects
Sesame Oil / pharmacology
Sex Factors
Testosterone / pharmacology
Reg. No./Substance:
0/Oils; 58-22-0/Testosterone; 8008-74-0/Sesame Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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