Document Detail


The effect of nefopam and its enantiomers on the uptake of 5-hydroxytryptamine, noradrenaline and dopamine in crude rat brain synaptosomal preparations.
MedLine Citation:
PMID:  1979627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of (+/-), (+) and (-)-nefopam on the uptake of 5-hydroxytryptamine (5-HT), noradrenaline and dopamine in synaptosomal preparations from rat forebrain, hippocampus and striatum has been investigated. All three forms of nefopam inhibited the amine uptake in the investigated structures, the order of potency being (+) greater than (+/-) greater than (-). (+)-Nefopam was 7-30 times more potent than (-)-nefopam. The same order of potency has also been found for the antinociceptive effect of these three forms, however, the differences were smaller. Inhibition of 5-HT and noradrenaline uptake may not be the sole mechanism underlying the analgesic effect of nefopam.
Authors:
J H Rosland; K Hole
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  42     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1991-01-25     Completed Date:  1991-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  437-8     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of Bergen, Norway.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism*
Corpus Striatum / drug effects,  metabolism
Dopamine / metabolism*
Hippocampus / drug effects,  metabolism
Male
Nefopam / pharmacology*
Norepinephrine / metabolism*
Rats
Rats, Inbred Strains
Serotonin / metabolism*
Stereoisomerism
Synaptosomes / drug effects,  metabolism*
Chemical
Reg. No./Substance:
13669-70-0/Nefopam; 50-67-9/Serotonin; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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