Document Detail

The effect of natural killer cell killer Ig-like receptor alloreactivity on the outcome of bone marrow stem cell transplantation for severe combined immunodeficiency (SCID).
MedLine Citation:
PMID:  17191149     Owner:  NLM     Status:  MEDLINE    
Natural killer (NK) cell alloreactions against recipient cells in the setting of bone marrow transplantation have been associated with decreased rates of graft-versus-host disease (GVHD) and improved survival in transplant recipients with myeloid leukemia. These alloreactions are predicted by the absence of recipient HLA class I ligands for donor inhibitory killer Ig-like receptors (KIR). We hypothesized that donor NK cell alloreactions against recipient cells may affect the development of T and B-cell functions and incidence of GVHD in infants with severe combined immunodeficiency (SCID). Of the 156 patients with SCID who had received related bone marrow transplants without pretransplant chemotherapy or posttransplant GVHD prophylaxis, 137 patient-donor pairs were evaluated for the absence of recipient HLA class I ligands for donor inhibitory KIR. Analysis showed that the absence of a KIR ligand had no effect on the incidence or severity of GVHD (RR [corrected] = 0.95, p = 0.84), development of T-cell function (RR [corrected] = 1.05, p = 0.69), production of IgA (p = 0.46) or IgM (p = 0.33), or on 5-year survival (RR [corrected] = 1.21, p = 0.10). Further, in patients possessing native NK cells, the absence of KIR ligands in donors for recipient-inhibitory KIR did not alter transplantation outcomes. This study suggests that inhibitory KIR/HLA interactions do not play a significant role in bone marrow transplantation for SCID.
M D Keller; D F Chen; S A Condron; N Liu; N L Reinsmoen; R H Buckley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-12-27
Journal Detail:
Title:  Journal of clinical immunology     Volume:  27     ISSN:  0271-9142     ISO Abbreviation:  J. Clin. Immunol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-02-08     Completed Date:  2007-05-08     Revised Date:  2008-01-31    
Medline Journal Info:
Nlm Unique ID:  8102137     Medline TA:  J Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-16     Citation Subset:  IM    
Division of Pediatric Allergy and Immunology, Duke University Medical Center, Durham, North Carolina, USA.
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MeSH Terms
Bone Marrow Transplantation / immunology*
Disease-Free Survival
Follow-Up Studies
Graft vs Host Disease / immunology
Hematopoietic Stem Cell Transplantation*
Histocompatibility Antigens / immunology
Histocompatibility Testing
Infant, Newborn
Killer Cells, Natural / immunology*
Lymphocyte Depletion / methods
Receptors, Immunologic / immunology*
Receptors, KIR
Retrospective Studies
Severe Combined Immunodeficiency / immunology*,  therapy*
Transplantation, Homologous
Treatment Outcome
Grant Support
5R01-AI/HD042951-07/AI/NIAID NIH HHS
Reg. No./Substance:
0/Histocompatibility Antigens; 0/Receptors, Immunologic; 0/Receptors, KIR
Erratum In:
J Clin Immunol. 2007 Nov;27(6):659

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