Document Detail


The effect of nasal decongestant on nasal mucous velocity.
MedLine Citation:
PMID:  80967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nasal mucous velocity was measured in 13 healthy nonsmokers before and 10 min after topical application of 2 alpha adrenergic nasal decongestant sprays, phenylephrine and tetrahydrozoline. Phenylephrine increased nasal mucous velocity from 8.4 +/- 2.7 mm per min (mean +/- SD) to 13.7 +/- 4.8 mm per min and tetrahydrozoline from 8.1 +/- 3.8 mm per min (mean +/- SD) to 13.8 +/- 5.1 mm per min. These increases were significant (P less than 0.01) when compared to topical application of phenylephrine and tetrahydrozoline vehicles, normal saline, and sham (empty aerosol container).
Authors:
K Saketkhoo; B M Yergin; A Januszkiewicz; K Kovitz; M A Sackner
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  118     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-11-18     Completed Date:  1978-11-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  251-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adult
Aerosols
Aged
Benzalkonium Compounds / pharmacology
Citrates / pharmacology
Drug Combinations
Drug Packaging
Edetic Acid / pharmacology
Female
Humans
Hydrochloric Acid / pharmacology
Imidazoles / pharmacology*
Male
Middle Aged
Mucus / drug effects*
Nasal Decongestants / administration & dosage,  pharmacology*
Nasal Mucosa / drug effects
Phenylephrine / pharmacology
Rheology
Sodium Chloride / pharmacology
Tetrahydronaphthalenes / pharmacology
Vehicles
Chemical
Reg. No./Substance:
0/Aerosols; 0/Benzalkonium Compounds; 0/Citrates; 0/Drug Combinations; 0/Imidazoles; 0/Nasal Decongestants; 0/Tetrahydronaphthalenes; 0/Vehicles; 59-42-7/Phenylephrine; 60-00-4/Edetic Acid; 7647-01-0/Hydrochloric Acid; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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