| The effect of naftidrofuryl on the metabolic response to exercise in man. | |
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MedLine Citation:
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PMID: 1155038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have designed this investigation to determine whether naftidrofuryl has an effect upon metabolism in vivo in man. Five subjects were studied during and after steady exercise on a bicycle ergometer. On the first occasion they received naftidrofuryl (300 mg orally) 20-40 min before exercise; and on the second they exercised without the drug to provide control observations. Blood samples were taken for the estimation of glucose, pyruvate, lactate, glycerol, acetoacetate and 3-hydroxybutyrate. Exercise with naftidrofuryl caused a significantly greater rise in blood pyruvate concentration during the exercise and post-exercise period compared with the controls. Changes in glucose, lactate, glycerol and ketone-bodies were not significantly different from the control values. Lactate/pyruvate ratios were significantly reduced with naftidrofuryl during the post-exercise period. Exercise causes a rise in intracellular anaerobic metabolism with associated increases in blood lactate/pyruvate ratios. This is followed by enhanced oxidative capacity during the recovery period as adduced from falling lactate/pyruvate ratios. The greater decline in lactate/pyruvate ratios with naftidrofuryl during the post-exercise period is evidence that naftidrofuryl is able to enhance cellular oxidative activity in vivo in man. Further studies in clinical situations are therefore indicated. |
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Authors:
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S W Shaw; R H Johnson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 52 ISSN: 0001-6314 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 1975 Sep |
Date Detail:
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Created Date: 1975-11-08 Completed Date: 1975-11-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 231-7 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetoacetates
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blood* Adult Blood Glucose* / analysis Furans / pharmacology* Glycerol / blood* Humans Hydroxybutyrates / blood* Ketone Bodies / blood Lactates / blood* Male Nafronyl / pharmacology* Oxygen Consumption Physical Exertion* Pyruvates / blood* Stimulation, Chemical Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Acetoacetates; 0/Blood Glucose; 0/Furans; 0/Hydroxybutyrates; 0/Ketone Bodies; 0/Lactates; 0/Pyruvates; 31329-57-4/Nafronyl; 56-81-5/Glycerol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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