| The effect of n-3 polyunsaturated fatty acids on leukotriene B(4) and leukotriene B(5) production from stimulated neutrophil granulocytes in patients with chronic kidney disease. | |
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MedLine Citation:
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PMID: 21530211 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The proinflammatory leukotriene B(4) (LTB(4)) may be of importance in the progression of chronic kidney disease (CKD). We investigated whether n-3 polyunsaturated fatty acids (PUFA) decrease LTB(4) and increase the formation of the less inflammatory leukotriene B(5) (LTB(5)) in patients with CKD. Fifty-six patients with CKD stage 2-5 were randomised to 2.4g n-3 PUFA or olive oil for 8 weeks. Compared to controls, n-3 PUFA significantly decreased release of LTB(4) (p<0.001) and 5-hydroxyeicosatetraenoic acid (5-HETE) (p<0.01) and significantly increased release of LTB(5) (p<0.001) and 5-hydroxyeicosapentaenoic acid (5-HEPE) (p<0.001) from stimulated neutrophil granulocytes. Kidney function evaluated by creatinine clearance and proteinuria did not improve. In conclusion, n-3 PUFA supplementation for 8 weeks in patients with CKD stage 2-5 significantly decreased LTB(4) and 5-HETE and significantly increased LTB(5) and 5-HEPE. No effect was seen on kidney function. |
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Authors:
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T Maaløe; E B Schmidt; M Svensson; I V Aardestrup; J H Christensen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-27 |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: - ISSN: 1532-2823 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-5-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Nephrology, Center for Cardiovascular Research Aalborg Hospital, Aarhus University Hospital, 9000 Aalborg, Denmark. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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