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The effect of n-3 polyunsaturated fatty acids on leukotriene B(4) and leukotriene B(5) production from stimulated neutrophil granulocytes in patients with chronic kidney disease.
MedLine Citation:
PMID:  21530211     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The proinflammatory leukotriene B(4) (LTB(4)) may be of importance in the progression of chronic kidney disease (CKD). We investigated whether n-3 polyunsaturated fatty acids (PUFA) decrease LTB(4) and increase the formation of the less inflammatory leukotriene B(5) (LTB(5)) in patients with CKD. Fifty-six patients with CKD stage 2-5 were randomised to 2.4g n-3 PUFA or olive oil for 8 weeks. Compared to controls, n-3 PUFA significantly decreased release of LTB(4) (p<0.001) and 5-hydroxyeicosatetraenoic acid (5-HETE) (p<0.01) and significantly increased release of LTB(5) (p<0.001) and 5-hydroxyeicosapentaenoic acid (5-HEPE) (p<0.001) from stimulated neutrophil granulocytes. Kidney function evaluated by creatinine clearance and proteinuria did not improve. In conclusion, n-3 PUFA supplementation for 8 weeks in patients with CKD stage 2-5 significantly decreased LTB(4) and 5-HETE and significantly increased LTB(5) and 5-HEPE. No effect was seen on kidney function.
Authors:
T Maaløe; E B Schmidt; M Svensson; I V Aardestrup; J H Christensen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-27
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  -     ISSN:  1532-2823     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-5-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Nephrology, Center for Cardiovascular Research Aalborg Hospital, Aarhus University Hospital, 9000 Aalborg, Denmark.
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