Document Detail

The effect of multiple sclerosis and gender on central and peripheral fatigue during 2-min MVC.
MedLine Citation:
PMID:  21036661     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: The aim of this study was to evaluate the effect of secondary progressive MS disease on central and peripheral fatigue in women and men during continuous 2-min maximal voluntary contractions (MVC) of the quadriceps muscle.
METHODS: We studied age-matched (40-50-years of age) healthy individuals (men, n=9; women, n=10) and MS patients (men, n=9; women, n=9). The inclusion criteria for MS patients were a Kurtzke Expanded Disability Status Score <4 and a Fatigue Severity Scale Score >5.
RESULTS: The electrically-induced torque, MVC, and voluntary activation (VA) values were significantly greater in healthy persons than in MS patients. At the end of exercise, the fatigue index of MVC and VA was greater in MS patients than in the healthy cohort, whereas the electrically-induced torque was significantly decreased in healthy individuals. Peripheral fatigue was directly correlated with VA in MS patients; in contrast, it was inversely correlated with VA in healthy men. The variability of torque increased significantly during exercise and did not depend on MS and gender.
CONCLUSIONS: MS increased central fatigue and diminished peripheral fatigue significantly during 2-min MVC; however, only peripheral fatigue was significantly greater in healthy men than in healthy women.
SIGNIFICANCE: These results suggest the specified pattern of central and peripheral fatigue in MS patients and could be further exploited for potential therapeutic uses, for instance, to model exercise-induced less central fatigue, and this may not be differentiated between men and women.
Albertas Skurvydas; Marius Brazaitis; Julija Andrejeva; Dalia Mickeviciene; Vytautas Streckis
Publication Detail:
Type:  Journal Article     Date:  2010-10-30
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  122     ISSN:  1872-8952     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  767-76     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Department of Applied Physiology and Physiotherapy, Lithuanian Academy of Physical Education, Sporto 6, LT-44221 Kaunas, Lithuania.
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