Document Detail

The effect of a mucopolysaccharide-cartilage complex healing ointment on Er:YAG laser resurfaced facial skin.
MedLine Citation:
PMID:  11966786     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There are several types of dressings which may be utilized after facial laser resurfacing. Laser surgeons favoring the open type of dressing have used the Aquaphor original formula to reduce the loss of moisture from laser resurfaced skin. The objective of this study was to compare the effectiveness of a mucopolysaccharide-cartilage complex (MCC) containing healing ointment with the standard therapy of Aquaphor ointment in treating erythema, edema, and skin erosion caused by Er:YAG laser resurfacing of facial skin. OBJECTIVE: To compare healing time after Er:YAG laser resurfacing treated side-by-side with MCC as compared with Aquaphor. METHODS: Nineteen patients completing Er:YAG laser resurfacing were randomly assigned to receive MCC healing ointment on one side of their face and standard therapy with Aquaphor on the other for eight consecutive treatment days. Immediately after surgery and again on days 1, 2, 3, 4, 7, and 8, the severity of erythema, edema, and erosion was scored on a 0-3 scale (0 = no observable effect, 1 = mild, 2 = moderate, 3 = severe). Photographs were taken at each follow-up visit. Following scoring on study day 0, the day of resurfacing, treatment was applied according to the left or right assignment code of the randomization schedule. RESULTS: Mean severity ratings for all variables (erythema, edema, and erosion) were consistently lower for MCC healing ointment as compared to Aquaphor ointment. Based on the calculated overall efficacy index, MCC ointment was statistically superior to Aquaphor for all three variables: erythema, P <.001; edema, P =.017; erosion, P <.001. CONCLUSION: The results of our study demonstrate that MCC healing ointment may provide an advantage over the standard therapy of Aquaphor ointment in the treatment of edema, erosion, and erythema caused by laser resurfacing of facial skin. Mean daily severity scores were consistently lower and improvement tended to occur earlier with MCC healing ointment.
Elizabeth L Tanzi; Maritza Perez
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  28     ISSN:  1076-0512     ISO Abbreviation:  Dermatol Surg     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-22     Completed Date:  2002-05-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  305-8     Citation Subset:  IM    
St. Lukes-Roosevelt Department of Dermatology, New York, New York 10019, USA.
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MeSH Terms
Edema / pathology,  therapy
Erythema / pathology,  therapy
Face / surgery*
Laser Therapy*
Middle Aged
Skin / surgery*
Tissue Extracts / therapeutic use*
Wound Healing*
Reg. No./Substance:
0/Glycosaminoglycans; 0/Ointments; 0/Tissue Extracts; 0/bovine cartilage extract

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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