| The effect of motilin on the rectum in healthy volunteers. | |
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MedLine Citation:
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PMID: 12814447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The role of motilin in the regulation of upper gastrointestinal (GI) motility is well defined. However, little is known about the effects on the distal GI tract. To investigate the effect of exogenous motilin on rectal function, barostat measurements in the rectum were performed and lower abdominal symptoms were scored. METHODS: Eight fasted, healthy volunteers were infused intravenously with synthetic motilin or placebo over 90 min in a double-blind, randomized, cross-over design. Rectum volume was measured with a barostat device during constant pressure and during isobaric distensions. Lower abdominal symptoms were scored by visual analogue scales. Plasma motilin concentrations were measured by radioimmunoassay. RESULTS: Baseline rectum volumes were similar between treatments: 185 +/- 62 mL (motilin) and 136 +/- 41 mL (placebo). During the constant pressure procedure, motilin increased rectum volume [area under the effect curve (AUEC)] by 6%[95% confidence interval (CI) -3, 16] of baseline, compared with placebo. During isobaric distensions motilin increased rectum volume (AUEC) by 43 mL (95% CI 0.4, 85; P < 0.05) and compliance by 10 mL mmHg-1 (95% CI 0.3, 20; P < 0.05) relative to placebo. Motilin did not induce changes in the sensation of rectal feelings. CONCLUSION: Exogenous motilin increased rectal compliance in healthy volunteers, without affecting rectal sensations. |
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Authors:
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I M C Kamerling; J Burggraaf; A D van Haarst; M F Oppenhuizen-Duinker; H C Schoemaker; I Biemond; R Jones; H Heinzerling; A F Cohen; A A M Masclee |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 55 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-19 Completed Date: 2003-08-26 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 538-43 Citation Subset: IM |
Affiliation:
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Centre for Human Drug Research, Leiden University Medical Centre, The Netherlands. ikamerli@chdr.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cross-Over Studies Double-Blind Method Female Gastrointestinal Agents / pharmacology* Humans Male Motilin / pharmacology* Pressure Rectum / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Agents; 52906-92-0/Motilin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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