| The effect of monoamine depletors on metrazol induced convulsions and brain gamma-aminobutyric acid (GABA) contents in rats. | |
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MedLine Citation:
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PMID: 2576059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The thresholds for metrazol (pentylenetetrazol) clonic convulsions and brain gamma-aminobutyric acid contents were significantly reduced after treatment with the monoamine depletors reserpine, tetrabenazine and p-chlorophenylalanine. Moreover, alpha-methyltyrosine, and alpha-methyl-m-tyrosine also lowered metrazol threshold seizures, but had no effect on brain alpha-aminobutyric acid contents. Furthermore, neither 5-hydroxytryptophan nor tranylcypromine had a significant effect on metrazol threshold seizures or brain alpha-aminobutyric acid contents, but blocked the changes previously induced by p-chlorophenyl alanine and reserpine. |
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Authors:
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W T Abed |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 41 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 1989 Nov |
Date Detail:
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Created Date: 1990-03-26 Completed Date: 1990-03-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 807-8 Citation Subset: IM |
Affiliation:
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Faculty of Medicine, Jordan University of Science and Technology, Irbid. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticonvulsants* Biogenic Monoamines / metabolism* Brain / drug effects, metabolism* Female Male Pentylenetetrazole* Rats Rats, Inbred Strains Seizures / chemically induced, physiopathology, prevention & control* gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Biogenic Monoamines; 54-95-5/Pentylenetetrazole; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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