| The effect of mono(2-ethylhexyl)phthalate on an isolated perfused rat heart-lung preparation. | |
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MedLine Citation:
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PMID: 2088746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Di(2-ethylhexyl)phthalate (DEHP), the plasticizer used in the biomedical production of blood storage bags, hemodialysis systems, cardiopulmonary bypass (CPB) circuitry, and intubation tubes, is extracted from the plastic material when it comes into contact with biological fluids and is converted to its principal metabolite, mono(2-ethylhexyl)phthalate (MEHP). We have shown that MEHP causes cardiac and respiratory arrest, as well as hypotension, when infused into anesthetized rats. Using a well-ventilated in vitro rat heart-lung preparation, we investigated the effect of MEHP on pulmonary artery pressure (PAP) and found that MEHP had a hypertensive effect on the pulmonary vasculature ending in constriction and edema. There was a significant increase of 0.58 mm Hg/min in the PAP of isolated rat lungs when perfused with MEHP dissolved in Krebs-Henseleit (K-H) buffer (p = 0.0003). The rat lungs that were perfused with K-H buffer only increased 0.094 mm Hg/min during the same perfusion time of 20 min. The water gained during this time was 0.22 g/min with MEHP in the buffer compared to 0.04 g/min with buffer alone. The pO2 in the effluent did not decrease during the perfusion time. The concentration of MEHP in the rat lungs after perfusion varied from 20 to 40 micrograms/g. Although the mechanism of action of MEHP on PAP is too complex to be fully elucidated by this model, the increase in PAP which we have demonstrated is significant and adds yet another toxic effect of this major metabolite of the ubiquitous plasticizer, DEHP. |
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Authors:
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R S Labow; Y A Barry; M Tocchi; W J Keon |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Environmental health perspectives Volume: 89 ISSN: 0091-6765 ISO Abbreviation: Environ. Health Perspect. Publication Date: 1990 Nov |
Date Detail:
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Created Date: 1991-05-28 Completed Date: 1991-05-28 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0330411 Medline TA: Environ Health Perspect Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 189-93 Citation Subset: IM |
Affiliation:
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University of Ottawa Heart Institute, Ottawa Civic Hospital, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Body Water / drug effects, metabolism Diethylhexyl Phthalate / toxicity* Heart / drug effects*, physiology Lung / drug effects*, physiology, ultrastructure Male Perfusion Plasticizers / toxicity Pulmonary Artery / drug effects Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Plasticizers; 117-81-7/Diethylhexyl Phthalate; 4376-20-9/mono-(2-ethylhexyl)phthalate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Environ Health Perspect ISSN: 0091-6765 |
Article Information Download PDF  Print publication date: Month: 11 Year: 1990 Volume: 89First Page: 189 Last Page: 193 ID: 1567782 PubMed Id: 2088746 |
| The effect of mono(2-ethylhexyl)phthalate on an isolated perfused rat heart-lung preparation. | |
| R S Labow | |
| Y A Barry | |
| M Tocchi | |
| W J Keon | |
| University of Ottawa Heart Institute, Ottawa Civic Hospital, Ontario, Canada. |
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