Document Detail

The effect of modified fasting on blood pressure and sympathetic activity: a correlation?
MedLine Citation:
PMID:  6654573     Owner:  NLM     Status:  MEDLINE    
The effect of a low calorie diet (200 kcal/0.8 MJ) composed of 50 per cent glucose and 50 per cent protein was studied on blood pressure and sympathetic activity in eight normotensive obese subjects. The study lasted 21 days; during the first seven days (period I) a weight maintaining diet was given; this was followed by 14 d (period II) of modified fasting (200 kcal/0.8 MJ). Sodium and potassium intakes of 20 and 80 mmol per d respectively were maintained constant throughout the study. In period I blood pressure decreased slightly until day 5; this occurred concomitantly with a marked natriuresis. Thereafter blood pressure and sodium excretion remained stable. No significant change was observed in the urinary excretion of total catecholamines, noradrenaline and 4-hydroxy-3-methoxy mandelic acid. From the start of period II blood pressure decreased markedly, together with a significant decrease in the urinary excretion of the catecholamines and 4-hydroxy-3-methoxy mandelic acid. Both blood pressure and urinary excretion of catecholamines and 4-hydroxy-3-methoxy mandelic acid stabilized after day 7 of period II. These changes preceded the maximal sodium diuresis of severe calorie restriction. The results suggest a primary role for the sympathetic system in the hypotensive effect of short term calorie deprivation although some influence of natriuresis cannot be excluded.
H P Koppeschaar; A E Meinders; F Schwarz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of obesity     Volume:  7     ISSN:  -     ISO Abbreviation:  Int J Obes     Publication Date:  1983  
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  7703240     Medline TA:  Int J Obes     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  569-74     Citation Subset:  IM    
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MeSH Terms
Blood Pressure*
Body Weight
Catecholamines / urine
Diet, Reducing
Diet, Sodium-Restricted
Obesity / diet therapy,  physiopathology*,  urine
Sympathetic Nervous System / physiopathology*
Vanilmandelic Acid / urine
Reg. No./Substance:
0/Catecholamines; 55-10-7/Vanilmandelic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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