| The effect of modified fasting on blood pressure and sympathetic activity: a correlation? | |
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MedLine Citation:
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PMID: 6654573 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of a low calorie diet (200 kcal/0.8 MJ) composed of 50 per cent glucose and 50 per cent protein was studied on blood pressure and sympathetic activity in eight normotensive obese subjects. The study lasted 21 days; during the first seven days (period I) a weight maintaining diet was given; this was followed by 14 d (period II) of modified fasting (200 kcal/0.8 MJ). Sodium and potassium intakes of 20 and 80 mmol per d respectively were maintained constant throughout the study. In period I blood pressure decreased slightly until day 5; this occurred concomitantly with a marked natriuresis. Thereafter blood pressure and sodium excretion remained stable. No significant change was observed in the urinary excretion of total catecholamines, noradrenaline and 4-hydroxy-3-methoxy mandelic acid. From the start of period II blood pressure decreased markedly, together with a significant decrease in the urinary excretion of the catecholamines and 4-hydroxy-3-methoxy mandelic acid. Both blood pressure and urinary excretion of catecholamines and 4-hydroxy-3-methoxy mandelic acid stabilized after day 7 of period II. These changes preceded the maximal sodium diuresis of severe calorie restriction. The results suggest a primary role for the sympathetic system in the hypotensive effect of short term calorie deprivation although some influence of natriuresis cannot be excluded. |
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Authors:
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H P Koppeschaar; A E Meinders; F Schwarz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of obesity Volume: 7 ISSN: 0307-0565 ISO Abbreviation: Int J Obes Publication Date: 1983 |
Date Detail:
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Created Date: 1984-02-14 Completed Date: 1984-02-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7703240 Medline TA: Int J Obes Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 569-74 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Pressure* Body Weight Catecholamines / urine Diet, Reducing Diet, Sodium-Restricted Fasting* Female Humans Natriuresis Obesity / diet therapy, physiopathology*, urine Sympathetic Nervous System / physiopathology* Vanilmandelic Acid / urine |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 55-10-7/Vanilmandelic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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