| The effect of mitomycin C in reducing intraarticular adhesion after knee surgery in rabbits. | |
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MedLine Citation:
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PMID: 20599934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mitomycin C (MMC) is known to inhibit fibroblast proliferation through suppressing DNA dependent RNA synthesis. Based on this knowledge, we illustrated the effect of MMC on inhibiting fibroblast collagen synthesis and reducing intraarticular fibrous adhesion in a rabbit model. Forty-eight New Zealand white rabbits were randomly divided into four groups. Approximately 10 x 10 mm squares of the cortical bone was removed from both sides of the femoral condyle, and the underneath cancellous bone was exposed. MMC in various concentrations or saline were then applied to the decorticated areas. The intraarticular adhesions were evaluated after four weeks by macroscopic evaluation, histological evaluation and biochemical analysis of hydroxyproline content. The results demonstrated that MMC could suppress the formation of intraarticular fibrous adhesion in a dose-dependent manner. The intraarticular adhesion score, the hydroxyproline content and the fibroblast number in 0.1mg/ml MMC group were significantly less than those in 0.05 mg/ml MMC group, 0.01 mg/ml MMC group and control group. However, dense adhesions were found in 0.01 mg/ml MMC group and control group. These results indicated that topical application of 0.1mg/ml MMC could reduce intraarticular adhesion through inhibiting fibroblast proliferation in rabbits. |
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Authors:
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Lianqi Yan; Yu Sun; Jingcheng Wang; Shanhe Dai; Xinmin Feng; Baichuan Jiang; Qiang Wang; Tangyun Yu; Xiaoming Shi; Jiandong Yang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-19 |
Journal Detail:
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Title: European journal of pharmacology Volume: 643 ISSN: 1879-0712 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1-5 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Orthopedics, Subei People's Hospital, Clinical Medical College of Yangzhou University, Nantong West Road 98, Yangzhou 225001, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Animals Cell Count Cicatrix / metabolism, pathology, prevention & control* Collagen / biosynthesis Disease Models, Animal Femur / metabolism, pathology, surgery* Fibroblasts / drug effects, metabolism, pathology Hydroxyproline / metabolism Male Mitomycin / administration & dosage, pharmacology, therapeutic use* Postoperative Complications / metabolism, pathology, prevention & control* Rabbits Tissue Adhesions / metabolism, pathology, prevention & control Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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50-07-7/Mitomycin; 51-35-4/Hydroxyproline; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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