Document Detail


The effect of minoxidil on blood pressure and plasma renin activity in patients with essential and renal hypertension.
MedLine Citation:
PMID:  790007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of the new vasodilator, minoxidil, on blood pressure and plasma renin activity was studied in 21 hypertensive patients: 12 patients with essential and 9 with renal hypertension. The average maximum dosage of minoxidil was 27.9 +/- 6.0 mg/day (M +/- SD). Average duration of treatment was 84.5 days. During the observation period the average systolic blood pressure fell from 195 +/- 18 to 159 +/- 7 mm Hg (M +/- SD), and the mean diastolic blood pressure fell from 120 +/- 8.3 to 92.5 +/- 8 mm Hg (p less than 0.01). These patients had been treated earlier with other antihypertensive agents, such as reserpine, saluretics, hydralazine, alpha-methyldopa, and clonidine, without any significant reduction in blood pressure. Before treatment, plasma renin activity after resting was 59 +/- 6.4 ng/ml/16 h (M +/- SE) and after saluretics and orthostasis 89 +/- 12.7 ng/ml/16 h. After treatment, the decline in renin value after resting was statistically significant: 42.7 +/- 3.3 ng/ml/16 h (p less than 0.05), and the stimulated renin had fallen to 70 +/- 3.4 ng/ml/16 h (p greater than 0.1). A comparison of the renin stimulation values of patients with renal hypertension also revealed a significant reduction (p less than 0.01). Side effects which appeared at a daily dose of 15 to 30 mg consisted mainly of tachycardia and fluid retention and could be controlled by the administration of propranolol and chlorthalidone. In 5 women and in 1 man was observed a cosmetically disturbing, reversible hypertrichosis. Orthostatic hypotension was observed in one patient. Minoxidil is an effective antihypertensive agent. However, because of its side effects, it generally must be administered with beta-receptor blocking agents and saluretics. It is possible that its blood pressure lowering effect is due, at least in part, to a suppression of the plasma renin activity.
Authors:
C Werning
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Klinische Wochenschrift     Volume:  54     ISSN:  0023-2173     ISO Abbreviation:  Klin. Wochenschr.     Publication Date:  1976 Aug 
Date Detail:
Created Date:  1976-12-30     Completed Date:  1976-12-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985205R     Medline TA:  Klin Wochenschr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  727-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure / drug effects*
Clinical Trials as Topic
Edema / chemically induced
Female
Humans
Hypertension / blood,  drug therapy*,  physiopathology
Hypertension, Renal / drug therapy*
Hypertrichosis / chemically induced
Male
Middle Aged
Minoxidil / adverse effects,  therapeutic use*
Pyrimidines / therapeutic use*
Renin / blood*
Tachycardia / chemically induced
Chemical
Reg. No./Substance:
0/Pyrimidines; 38304-91-5/Minoxidil; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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