| The effect of minoxidil on blood pressure and plasma renin activity in patients with essential and renal hypertension. | |
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MedLine Citation:
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PMID: 790007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of the new vasodilator, minoxidil, on blood pressure and plasma renin activity was studied in 21 hypertensive patients: 12 patients with essential and 9 with renal hypertension. The average maximum dosage of minoxidil was 27.9 +/- 6.0 mg/day (M +/- SD). Average duration of treatment was 84.5 days. During the observation period the average systolic blood pressure fell from 195 +/- 18 to 159 +/- 7 mm Hg (M +/- SD), and the mean diastolic blood pressure fell from 120 +/- 8.3 to 92.5 +/- 8 mm Hg (p less than 0.01). These patients had been treated earlier with other antihypertensive agents, such as reserpine, saluretics, hydralazine, alpha-methyldopa, and clonidine, without any significant reduction in blood pressure. Before treatment, plasma renin activity after resting was 59 +/- 6.4 ng/ml/16 h (M +/- SE) and after saluretics and orthostasis 89 +/- 12.7 ng/ml/16 h. After treatment, the decline in renin value after resting was statistically significant: 42.7 +/- 3.3 ng/ml/16 h (p less than 0.05), and the stimulated renin had fallen to 70 +/- 3.4 ng/ml/16 h (p greater than 0.1). A comparison of the renin stimulation values of patients with renal hypertension also revealed a significant reduction (p less than 0.01). Side effects which appeared at a daily dose of 15 to 30 mg consisted mainly of tachycardia and fluid retention and could be controlled by the administration of propranolol and chlorthalidone. In 5 women and in 1 man was observed a cosmetically disturbing, reversible hypertrichosis. Orthostatic hypotension was observed in one patient. Minoxidil is an effective antihypertensive agent. However, because of its side effects, it generally must be administered with beta-receptor blocking agents and saluretics. It is possible that its blood pressure lowering effect is due, at least in part, to a suppression of the plasma renin activity. |
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Authors:
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C Werning |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Klinische Wochenschrift Volume: 54 ISSN: 0023-2173 ISO Abbreviation: Klin. Wochenschr. Publication Date: 1976 Aug |
Date Detail:
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Created Date: 1976-12-30 Completed Date: 1976-12-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985205R Medline TA: Klin Wochenschr Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 727-34 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Pressure / drug effects* Clinical Trials as Topic Edema / chemically induced Female Humans Hypertension / blood, drug therapy*, physiopathology Hypertension, Renal / drug therapy* Hypertrichosis / chemically induced Male Middle Aged Minoxidil / adverse effects, therapeutic use* Pyrimidines / therapeutic use* Renin / blood* Tachycardia / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Pyrimidines; 38304-91-5/Minoxidil; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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