| The effect of mild temperature hyperthermia on tumour hypoxia and blood perfusion: relevance for radiotherapy, vascular targeting and imaging. | |
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MedLine Citation:
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PMID: 20230250 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinically achievable mild temperature local hyperthermia (<43 degrees C) has been demonstrated to be an effective adjuvant to radiotherapy in pre-clinical and clinical studies. In this article, we briefly review the recent progress in the following areas: (1) the effect of mild temperature hyperthermia (MTH) on tumour hypoxia and blood perfusion as assessed by dual marker immunohistochemistry (IHC); (2) the kinetics of MTH induced changes in tumour hypoxia; (3) the potential role of heat-induced tumour reoxygenation on radio- and chemo-sensitisation; (4) the potential role of MTH in combination with vascular targeting agents (VTAs) on tumour response; and (5) non-invasive detection of changes in tumour oxygenation and blood perfusion. It is shown that MTH, by itself or in combination with VTAs, leads to changes in tumour perfusion and oxygenation with potential for radio- and chemo-sensitisation. |
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Authors:
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Xiaorong Sun; Ligang Xing; C Clifton Ling; Gloria C Li |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group Volume: 26 ISSN: 1464-5157 ISO Abbreviation: Int J Hyperthermia Publication Date: 2010 |
Date Detail:
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Created Date: 2010-04-14 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508395 Medline TA: Int J Hyperthermia Country: England |
Other Details:
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Languages: eng Pagination: 224-31 Citation Subset: IM |
Affiliation:
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Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia Hemorheology Humans Hyperthermia, Induced / methods* Microcirculation* Neoplasms / blood supply*, therapy* Oxygen Consumption Radiation Tolerance |
| Grant Support | |
ID/Acronym/Agency:
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CA109772/CA/NCI NIH HHS; CA56909/CA/NCI NIH HHS; P01CA115675/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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