Document Detail

The effect of mild post-stroke exercise on reactive neurogenesis and recovery of somatosensation in aged rats.
MedLine Citation:
PMID:  20696163     Owner:  NLM     Status:  MEDLINE    
Exercise impacts the cellular response and behavioral recovery following stroke, but has not been widely investigated in aged animals. We tested the hypothesis that gentle post-stroke exercise could enhance recovery of somatosensory function and influence survival and phenotype of newly generated cells in the peri-infarct region after focal cortical ischemia in aged rats. Focal stroke was induced in the forelimb area of the sensorimotor cortex in 18-month old male rats using the vasoconstrictor endothelin-1. Beginning 1 week after stroke or sham surgery, half of the animals walked 100-300 m daily, 5 days per week. Bromodeoxyuridine (BrdU) was administered on days 6-8 post-stroke in order to label proliferating cells, the survival and phenotype of which were examined 4 weeks later using confocal microscopy. Post-stroke exercise enhanced recovery of somatosensory function as measured by the Adhesive Removal Test. Stroke, but not exercise, increased the number of BrdU+ cells in the peri-infarct region. In aged rats, mild post-stroke exercise enhances recovery of somatosensation, but has little effect on survival and phenotype of cells born in response to ischemia. Our results underscore the need for further study of clinically relevant post-stroke exercise regimens.
J Leigh Leasure; Michael Grider
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-07
Journal Detail:
Title:  Experimental neurology     Volume:  226     ISSN:  1090-2430     ISO Abbreviation:  Exp. Neurol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-15     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-67     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Department of Psychology, University of Houston, Houston, TX 77204, USA.
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MeSH Terms
Antimetabolites / diagnostic use
Brain Ischemia / complications,  pathology
Bromodeoxyuridine / diagnostic use
Cerebral Infarction / pathology
Dentate Gyrus / pathology,  physiopathology
Forelimb / innervation,  physiology
Neurogenesis / physiology*
Physical Conditioning, Animal / physiology*
Rats, Inbred F344
Recovery of Function / physiology*
Somatosensory Cortex / pathology,  physiopathology*
Stem Cells / physiology
Stroke / etiology,  physiopathology,  rehabilitation*
Walking / physiology
Weight Loss / physiology
Reg. No./Substance:
0/Antimetabolites; 59-14-3/Bromodeoxyuridine

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