| The effect of the methanol extract of galium mite on the cellular immunity and antibody synthesis. | |
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MedLine Citation:
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PMID: 21574089 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In the present study, the immunomodulatory effects of Galium mite, a native herb used for the treatment of inflammation in Iranian traditional medicine, was investigated. The methanolic extract of the plant was prepared and examined for in vivo cell-mediated and humoral immunity against antigen in mice. Galium mite stimulated delayed type hypersensitivity at lower concentrations and inhibited the reaction at higher ones (p < 0.05). A dose-related decrease in primary and secondary antibody titer was observed in mice treated with the extract (p < 0.006). The extract at higher concentrations significantly reduced the proliferation of human-activated lymphocytes (p < 0.001). Cell cycle analysis on human lymphocytes treated with the extract showed an increase in the number of cells in sub-G1 region, indicating the ability of the extract to induce apoptosis in these cells. Induction of apoptosis was confirmed by DNA laddering on gel electrophoresis. In conclusion, G. mite has the ability to modulate cellular and humoral immune responses to the antigenic challenge and affect the rate of cell proliferation due to induction of apoptosis in the lymphocytes. |
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Authors:
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Zahra Amirghofran; Katayoun Javidnia; Masood Bahmani; Abbas Azadmehr; Maryam Esmaeilbeig |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of immunoassay & immunochemistry Volume: 32 ISSN: 1532-4230 ISO Abbreviation: J Immunoassay Immunochem Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-05-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100963688 Medline TA: J Immunoassay Immunochem Country: England |
Other Details:
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Languages: eng Pagination: 157-69 Citation Subset: IM |
Affiliation:
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Department of Immunology, Shiraz University of Medical Sciences, Shiraz, I. R. Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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