| The effect of medial hypothalamus lesions on pain control. | |
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MedLine Citation:
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PMID: 7407629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the rat, discrete electrolytic lesions located in 6 different parts of the medial hypothalamus (MH) are shown to induce clearcut hyperalgesia. During a time limit of 14 days following the lesions, no other obvious deficits were noticed (in sensory and/or motor functions, affectivity towards conspecifics, food and water intake). Three nociceptive reactions (tail withdrawal, vocalization, vocalization after-discharge) were tested and their thresholds measured following electrical stimulation of the tail. The lesions aimed at the rostral part of the arcuate nucleus, as well as at ventromedial and dorsomedial nuclei, produced the most profound hyperalgesia. The possible involvement of the endorphinergic and enkephalinergic systems known to be located in the MH is discussed. The relation between the hyperalgesic effects of MH lesions and various structures (limbic areas, descending pain control system, pituitary) is also considered. |
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Authors:
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C Vidal; J Jacob |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 199 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1980 Oct |
Date Detail:
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Created Date: 1980-11-25 Completed Date: 1980-11-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 89-100 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Mapping Hypothalamus / physiology* Hypothalamus, Middle / physiology* Male Nociceptors / physiology* Rats Sensory Thresholds |
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