Document Detail

The effect of medial hypothalamus lesions on pain control.
MedLine Citation:
PMID:  7407629     Owner:  NLM     Status:  MEDLINE    
In the rat, discrete electrolytic lesions located in 6 different parts of the medial hypothalamus (MH) are shown to induce clearcut hyperalgesia. During a time limit of 14 days following the lesions, no other obvious deficits were noticed (in sensory and/or motor functions, affectivity towards conspecifics, food and water intake). Three nociceptive reactions (tail withdrawal, vocalization, vocalization after-discharge) were tested and their thresholds measured following electrical stimulation of the tail. The lesions aimed at the rostral part of the arcuate nucleus, as well as at ventromedial and dorsomedial nuclei, produced the most profound hyperalgesia. The possible involvement of the endorphinergic and enkephalinergic systems known to be located in the MH is discussed. The relation between the hyperalgesic effects of MH lesions and various structures (limbic areas, descending pain control system, pituitary) is also considered.
C Vidal; J Jacob
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  199     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1980 Oct 
Date Detail:
Created Date:  1980-11-25     Completed Date:  1980-11-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  89-100     Citation Subset:  IM    
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MeSH Terms
Brain Mapping
Hypothalamus / physiology*
Hypothalamus, Middle / physiology*
Nociceptors / physiology*
Sensory Thresholds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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