Document Detail

The effect of mechanical stress on hypertrophy of the lumbar ligamentum flavum.
MedLine Citation:
PMID:  7606119     Owner:  NLM     Status:  MEDLINE    
To clarify the effect of mechanical stress on hypertrophy of the ligamentum flavum (LF), we compared the thicknesses, histological findings, and total collagen content of 161 lumbar LF in two groups defined by radiographic signs. LF with one or more signs of spondylolisthesis, disk degeneration, vacuum phenomenon, traction spur, or facet joint osteoarthrosis were considered degenerative; all others were considered nondegenerative. Thickness was measured by computed tomographic scan, and total collagen content by Woessner's method. We found that the ligament was thicker in the degenerative group (4.0 +/- 1.1 mm vs. 3.0 +/- 0.7 mm, p < 0.01), the degeneration of fibers more severe, and the total collagen content higher (51.9 +/- 14.5% vs. 40.3 +/- 3.9%, p < 0.05). Thus, mechanical stress is considered a cause of ligament hypertrophy.
S Fukuyama; T Nakamura; T Ikeda; K Takagi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of spinal disorders     Volume:  8     ISSN:  0895-0385     ISO Abbreviation:  J Spinal Disord     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-08-11     Completed Date:  1995-08-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8904842     Medline TA:  J Spinal Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  126-30     Citation Subset:  IM    
Department of Orthopaedic Surgery, Kumamoto University School of Medicine, Japan.
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MeSH Terms
Aged, 80 and over
Collagen / analysis
Joint Instability / pathology
Ligamentum Flavum / chemistry,  pathology*,  radiography
Middle Aged
Spinal Diseases / pathology
Spinal Stenosis / etiology
Stress, Mechanical
Tomography, X-Ray Computed
Reg. No./Substance:

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