Document Detail

The effect of meal replacements high in glycomacropeptide on weight loss and markers of cardiovascular disease risk.
MedLine Citation:
PMID:  18541546     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Glycomacropeptide (GMP) is a peptide that has been shown to stimulate release of cholecystokinin, which may promote satiety. OBJECTIVE: The aim of this one-year study was to examine whether greater weight loss could be achieved and sustained with a GMP-enriched whey powder supplement compared with a skim milk powder supplement. DESIGN: In a double-blind, randomized, parallel-design study using meal replacements, weight, body composition (determined by dual-energy X-ray absorptiometry), blood pressure, fasting lipids, glucose, and insulin were measured at baseline, 6, and 12 mo. Meal replacements contained 15 g protein from GMP-enriched whey protein isolate (GMP-WPI) or skim milk powder (SMP) and 900 kJ/sachet. Volunteers consumed 2 sachets/d instead of 2 meals for 6 mo and 1 sachet/d for a further 6 mo. Of the 127 participants (95 women, 32 men, 95.5 +/- 15.4 kg, body mass index 33.4 +/- 3.4 kg/m(2), 50.0 +/- 12.4 y), 82 completed the 6-mo study and 72 of those completed the 12-mo study. RESULTS: At 6 mo, weight loss was 9.5 +/- 5.8 kg compared with 11.0 +/- 6.0, GMP-WPI and SMP, respectively, and 9.9 +/- 8.8 kg compared with 10.8 +/- 7.4 GMP-WPI and SMP, respectively, at 12 mo (P < 0.001 compared with baseline, at both timepoints) with no differences between treatments. Total and LDL cholesterol, triacylglycerols, glucose, insulin, and systolic and diastolic blood pressure decreased at 6 and 12 mo (all P < 0.01 compared with baseline with no difference between treatments). HDL cholesterol increased at 12 mo (P < 0.001 compared with baseline). CONCLUSIONS: Meal replacements containing GMP had no additional effect on the overall sustained 12-mo weight loss of 10 kg. There were improvements in cardiovascular disease risk markers.
Jennifer B Keogh; Peter Clifton
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  87     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-10     Completed Date:  2008-08-01     Revised Date:  2009-05-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1602-5     Citation Subset:  AIM; IM    
Commonwealth Scientific and Industrial Research Organization, Human Nutrition, Adelaide, South Australia, Australia.
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MeSH Terms
Biological Markers
Blood Glucose / analysis
Body Composition
Body Height
Body Weight
Cardiovascular Diseases / epidemiology*
Dietary Proteins
Double-Blind Method
Glycopeptides / administration & dosage*
Insulin / blood
Lipids / blood
Middle Aged
Weight Loss*
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Caseins; 0/Dietary Proteins; 0/Glycopeptides; 0/Lipids; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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