| The effect of maternal undernutrition in early gestation on gestation length and fetal and postnatal growth in sheep. | |
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MedLine Citation:
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PMID: 17667859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In utero undernutrition in humans may result in cardiovascular (CV), metabolic, and growth adaptations. In sheep, maternal nutrient restriction during pregnancy, without effects on fetal or birth weight, results in altered CV control in the offspring. Adjustment of gestation length after undernutrition could be a strategy to enhance postnatal health/survival. The aim of this study was to determine in sheep the effect of a 50% reduction in maternal nutrient intake [undernutrition group (U) versus 100%, control group (C)] during 1-31 d of gestation (dGA) on gestation length and offspring size. By 28 dGA, U ewes had gained less weight than C, and twin-bearing ewes had gained less weight than singleton-bearing ewes regardless of group (p<0.05). In different-sex twin pairs, maternal undernutrition resulted in longer gestation compared with C (146.5+/-0.6 versus 144.6+/-0.6 d, p<0.05). Increased weight gain by weaning (20.8+/-0.8 versus 17.9+/-0.8 kg, p<0.05) was observed in U male twins. These findings suggest that the strategy (i.e. growth rate or length of time in utero) adopted by the fetus to enhance immediate survival depends on offspring number and sex. This is likely to reflect the degree of constraint imposed on the fetus. |
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Authors:
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Jane K Cleal; Kirsten R Poore; James P Newman; David E Noakes; Mark A Hanson; Lucy R Green |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric research Volume: 62 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-24 Completed Date: 2007-11-13 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 422-7 Citation Subset: IM |
Affiliation:
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Centre for Developmental Origins of Health and Disease, University of Southampton, Southampton, SO16 5YA United Kingdom. jcleal@soton.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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blood Animals Birth Weight Body Weight* Cardiovascular Diseases / embryology*, physiopathology Female Fetal Nutrition Disorders / etiology*, pathology, physiopathology Fetal Weight Gestational Age* Hydrocortisone / blood Kaplan-Meiers Estimate Male Malnutrition / complications*, pathology, physiopathology Organ Size Placenta / pathology Pregnancy Prenatal Nutritional Physiological Phenomena* Sheep Twins |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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