Document Detail

The effect of maternal undernutrition in early gestation on gestation length and fetal and postnatal growth in sheep.
MedLine Citation:
PMID:  17667859     Owner:  NLM     Status:  MEDLINE    
In utero undernutrition in humans may result in cardiovascular (CV), metabolic, and growth adaptations. In sheep, maternal nutrient restriction during pregnancy, without effects on fetal or birth weight, results in altered CV control in the offspring. Adjustment of gestation length after undernutrition could be a strategy to enhance postnatal health/survival. The aim of this study was to determine in sheep the effect of a 50% reduction in maternal nutrient intake [undernutrition group (U) versus 100%, control group (C)] during 1-31 d of gestation (dGA) on gestation length and offspring size. By 28 dGA, U ewes had gained less weight than C, and twin-bearing ewes had gained less weight than singleton-bearing ewes regardless of group (p<0.05). In different-sex twin pairs, maternal undernutrition resulted in longer gestation compared with C (146.5+/-0.6 versus 144.6+/-0.6 d, p<0.05). Increased weight gain by weaning (20.8+/-0.8 versus 17.9+/-0.8 kg, p<0.05) was observed in U male twins. These findings suggest that the strategy (i.e. growth rate or length of time in utero) adopted by the fetus to enhance immediate survival depends on offspring number and sex. This is likely to reflect the degree of constraint imposed on the fetus.
Jane K Cleal; Kirsten R Poore; James P Newman; David E Noakes; Mark A Hanson; Lucy R Green
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  62     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-24     Completed Date:  2007-11-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422-7     Citation Subset:  IM    
Centre for Developmental Origins of Health and Disease, University of Southampton, Southampton, SO16 5YA United Kingdom.
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MeSH Terms
Adrenocorticotropic Hormone / blood
Birth Weight
Body Weight*
Cardiovascular Diseases / embryology*,  physiopathology
Fetal Nutrition Disorders / etiology*,  pathology,  physiopathology
Fetal Weight
Gestational Age*
Hydrocortisone / blood
Kaplan-Meiers Estimate
Malnutrition / complications*,  pathology,  physiopathology
Organ Size
Placenta / pathology
Prenatal Nutritional Physiological Phenomena*
Reg. No./Substance:
50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone

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