Document Detail


The effect of maternal undernutrition in early gestation on gestation length and fetal and postnatal growth in sheep.
MedLine Citation:
PMID:  17667859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In utero undernutrition in humans may result in cardiovascular (CV), metabolic, and growth adaptations. In sheep, maternal nutrient restriction during pregnancy, without effects on fetal or birth weight, results in altered CV control in the offspring. Adjustment of gestation length after undernutrition could be a strategy to enhance postnatal health/survival. The aim of this study was to determine in sheep the effect of a 50% reduction in maternal nutrient intake [undernutrition group (U) versus 100%, control group (C)] during 1-31 d of gestation (dGA) on gestation length and offspring size. By 28 dGA, U ewes had gained less weight than C, and twin-bearing ewes had gained less weight than singleton-bearing ewes regardless of group (p<0.05). In different-sex twin pairs, maternal undernutrition resulted in longer gestation compared with C (146.5+/-0.6 versus 144.6+/-0.6 d, p<0.05). Increased weight gain by weaning (20.8+/-0.8 versus 17.9+/-0.8 kg, p<0.05) was observed in U male twins. These findings suggest that the strategy (i.e. growth rate or length of time in utero) adopted by the fetus to enhance immediate survival depends on offspring number and sex. This is likely to reflect the degree of constraint imposed on the fetus.
Authors:
Jane K Cleal; Kirsten R Poore; James P Newman; David E Noakes; Mark A Hanson; Lucy R Green
Related Documents :
15865489 - Efficacy of yoga on pregnancy outcome.
6897319 - Localization of tritiated 1,25-dihydroxy vitamin d3 in fetal rat mandible, kidney, and ...
19300329 - Influence of maternal body mass index on the clinical estimation of fetal weight in ter...
7776299 - Mass antimicrobial treatment in pregnancy. a randomized, placebo-controlled trial in a ...
7784919 - Macrosomia--maternal and fetal risk factors.
9814889 - Parameter estimates for direct, maternal, and grandmaternal genetic effects for birth w...
15823619 - Fetal growth restriction is associated with increased apoptosis in the chorionic tropho...
18827859 - Performance of the optimal dipstick in the diagnosis of malaria infection in pregnancy.
3535159 - Cellular localisation in placenta of placental type plasminogen activator inhibitor.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  62     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-24     Completed Date:  2007-11-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422-7     Citation Subset:  IM    
Affiliation:
Centre for Developmental Origins of Health and Disease, University of Southampton, Southampton, SO16 5YA United Kingdom. jcleal@soton.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / blood
Animals
Birth Weight
Body Weight*
Cardiovascular Diseases / embryology*,  physiopathology
Female
Fetal Nutrition Disorders / etiology*,  pathology,  physiopathology
Fetal Weight
Gestational Age*
Hydrocortisone / blood
Kaplan-Meiers Estimate
Male
Malnutrition / complications*,  pathology,  physiopathology
Organ Size
Placenta / pathology
Pregnancy
Prenatal Nutritional Physiological Phenomena*
Sheep
Twins
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Bone mineral content and body composition in overweight children and adolescents.
Next Document:  Toll-like receptor 2 polymorphism is associated with preterm birth.