Document Detail


The effect of maternal soluble FMS-like tyrosine kinase 1 during pregnancy on risk of preterm delivery.
MedLine Citation:
PMID:  22348624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Soluble fms-like tyrosine kinase 1 (sFlt1) is an antiangiogenic protein that is associated with a number of disorders of placental angiogenesis. It has been hypothesized that disruption of placental angiogenesis may contribute to the pathophysiology of preterm delivery (PTD). However, the relationship of PTD risk to variation in sFlt1 levels is not well known. We investigate the relationship between longitudinal variation in maternal serum concentrations of sFlt1 and risk of PTD.
METHODS: Data were collected in a longitudinal cohort study involving 278 pregnant women. Maternal serum sFlt1 concentrations were measured at 6-10, 10-14, 16-20, 22-26, and 32-36 weeks gestation. Data analyses used longitudinal regression models using repeated measures that allow robust inferences from our modest sample size. The outcome was birth prior to 37 weeks gestation.
RESULTS: sFlt1 concentrations were higher in first trimester for preterm compared to term deliveries. This relationship reversed in second trimester because sFlt1 concentrations increased more rapidly across gestation for term deliveries. In Cox proportional hazards analyses, a 2 ng higher sFlt1 concentration across gestation was associated with a hazard ratio of 1.3 (95% CI: 1.1, 1.5) for PTD suggesting the importance of levels in early pregnancy.
CONCLUSION: Elevated maternal serum sFlt1 concentration during pregnancy is associated with increased risk of PTD.
Authors:
Jennifer K Straughen; Pawan Kumar; Vinod K Misra
Related Documents :
19835504 - Social issues around advanced unwanted pregnancies in rural single women.
7965194 - Clues to positive birth outcomes in new mexico.
22377654 - Temporal effect of afro-caribbean race on serum pregnancy-associated plasma protein-a a...
2065874 - Symptom reporting in wanted and unwanted pregnancies.
24117104 - Causes of stillbirth at different gestational ages in singleton pregnancies.
10702524 - Detection and measurement of urinary 2-hydroxyestradiol 17-sulfate, a potential placent...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-03-27
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  25     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-18     Completed Date:  2013-03-17     Revised Date:  2014-10-18    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1879-83     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biological Markers / blood
Enzyme-Linked Immunosorbent Assay
Female
Humans
Linear Models
Longitudinal Studies
Maternal Serum Screening Tests
Middle Aged
Pilot Projects
Placenta Diseases / blood*
Pregnancy
Pregnancy Trimester, First / blood
Pregnancy Trimester, Second / blood
Premature Birth / blood,  diagnosis,  etiology*
Proportional Hazards Models
Prospective Studies
Risk Factors
Vascular Endothelial Growth Factor Receptor-1 / blood*
Young Adult
Grant Support
ID/Acronym/Agency:
5-P50-CA097248/CA/NCI NIH HHS; K08 HD045609/HD/NICHD NIH HHS; K08-HD045609/HD/NICHD NIH HHS; K12 CA133250/CA/NCI NIH HHS; K12 HD028820/HD/NICHD NIH HHS; K12-HD028820/HD/NICHD NIH HHS; M01 RR000042/RR/NCRR NIH HHS; M01-RR000042/RR/NCRR NIH HHS; UL1 RR024986/RR/NCRR NIH HHS; UL1RR024986/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; EC 2.7.10.1/FLT1 protein, human; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Objective predictors of delayed-onset post-traumatic stress disorder occurring after military discha...
Next Document:  Study protocol for the recruitment of female sex workers and their non-commercial partners into coup...