| The effect of maternal milk on neonatal morbidity of very low-birth-weight infants. | |
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MedLine Citation:
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PMID: 12517197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the dose effect of maternal milk on neonatal morbidity of very low-birth-weight (<1.5 kg) infants. DESIGN: Prospective observational study. SETTING: An urban tertiary care neonatal intensive care unit and follow-up clinic. POPULATION: One hundred nineteen singleton very low-birth-weight infants admitted from January 1, 1997, to February 14, 1999 (mean birth weight, 1056 g; mean gestational age, 28 weeks; 57% male; and 43% white). METHODS: A comparison of the effect on neonatal outcomes of daily graded doses (1-24, 25-49, and > or = 50 mL/kg of body weight) of maternal milk through week 4 of life vs a reference group receiving no maternal milk. MAIN OUTCOME MEASURES: Neonatal outcomes examined included rates of sepsis after age 5 days, retinopathy of prematurity, chronic lung disease, necrotizing enterocolitis, jaundice, duration of ventilator dependence, and length of hospital stay. RESULTS: Seventy-nine infants (66%) received maternal milk, of whom 32 received at least 50 mL/kg per day through week 4 of life. Poisson regression analysis adjusting for birth weight, sex, and ethnicity revealed that the mean number of episodes of sepsis for infants receiving at least 50 mL/kg per day was lower by a factor of 0.27 (95% confidence interval, 0.08-0.95) compared with infants receiving no maternal milk. There was no effect of maternal milk on other neonatal outcomes. CONCLUSIONS: A daily threshold amount of at least 50 mL/kg of maternal milk through week 4 of life is needed to decrease the rate of sepsis in very low-birth-weight infants, but maternal milk does not affect other neonatal morbidities. |
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Authors:
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Lydia Furman; Gerry Taylor; Nori Minich; Maureen Hack |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of pediatrics & adolescent medicine Volume: 157 ISSN: 1072-4710 ISO Abbreviation: Arch Pediatr Adolesc Med Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-01-08 Completed Date: 2003-01-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9422751 Medline TA: Arch Pediatr Adolesc Med Country: United States |
Other Details:
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Languages: eng Pagination: 66-71 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Case Western Reserve University, and Rainbow Babies and Children's Hospital, University Hospitals of Cleveland, Cleveland, Ohio, USA. lmfurman@att.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Infant Food* Infant Nutritional Physiological Phenomena Infant, Newborn Infant, Newborn, Diseases / epidemiology, prevention & control* Infant, Very Low Birth Weight Intensive Care Units, Neonatal Male Milk, Human* Poisson Distribution Sepsis / prevention & control |
| Grant Support | |
ID/Acronym/Agency:
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MO100080//PHS HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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