Document Detail

The effect of maternal magnesium sulfate treatment on neonatal morbidity in < or = 1000-gram infants.
MedLine Citation:
PMID:  10064205     Owner:  NLM     Status:  MEDLINE    
We evaluated the effect of maternal magnesium sulfate treatment on selected neonatal outcomes in < or =1000-g infants. In a 1-year (1992-1993) observational study, the National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units collected outcome data for 799 infants whose birth weights were < or =1000 g. Only singleton infants, with a gestational age >20 weeks who were not the product of an induced abortion were included. Our analysis was further limited to those infants without major congenital anomalies, who were deemed potentially viable by the obstetrician, whose mother would have undergone a cesarean delivery for fetal indications, and who survived greater than 2 days. Outcomes were compared in infants whose mothers did and did not receive magnesium sulfate for labor tocolysis. Among the 124 women who did and the 184 who did not receive magnesium sulfate tocolytic therapy, the frequencies of grade III or IV intraventricular hemorrhage (16 vs. 20%, p = 0.34), seizure activity (7 vs. 10%, p = 0.35), grade III or IV retinopathy of prematurity (21 vs. 18% p = 0.59), abnormal neurological exam (28 vs. 28%, p = 0.91), intact survival to 120 days or to discharge (48 vs. 44%, p = 0.54), and infant mortality (23 vs. 31%, p = 0.10) were similar. Multiple logistic regression analysis was used to control for the effect of potential confounders (specifically, gestational age) and confirmed the lack of a significant association between maternal magnesium sulfate treatment for tocolysis and selected neonatal outcomes in this population of < or =1000-gram infants.
D F Kimberlin; J C Hauth; R L Goldenberg; S F Bottoms; J D Iams; B Mercer; C MacPherson; G R Thurnau
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  15     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1998  
Date Detail:
Created Date:  1999-04-22     Completed Date:  1999-04-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  635-41     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 35233-7333, USA.
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MeSH Terms
Infant, Newborn
Infant, Newborn, Diseases
Infant, Very Low Birth Weight*
Logistic Models
Magnesium Sulfate / therapeutic use*
Pregnancy Outcome*
Retrospective Studies
Tocolytic Agents / therapeutic use*
Reg. No./Substance:
0/Tocolytic Agents; 7487-88-9/Magnesium Sulfate

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