Document Detail


The effect of maternal hypoaminoacidaemia on placental uptake and transport of amino acids in pregnant sheep.
MedLine Citation:
PMID:  11170820     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We developed a model of maternal hyperglycaemia with secondary hyperinsulinaemia and hypoaminoacidaemia in pregnant sheep (H) to determine the effect of these conditions on uterine, uteroplacental and fetal amino-acid uptake rates and fetal amino-acid concentrations [AA]. Results were compared with normal pregnant ewes (C). Plasma glucose concentrations were greater in H versus C animals: 7.7+/-0.3 versus 3.9+/-0.1 mmol/l maternal, P< 0.005; 2.6+/-0.1 versus 1.1+/-0.1 mmol/l fetal, P< 0.005. Maternal insulin concentrations [I] were greater in the H group (132+/-30 H versus 31+/-5 C microU/ml, P< 0.005); fetal [I] were not different (15+/-2 H versus 16+/-2 C microU/mL). Maternal [AA] were lower in H than C groups except for SER (P=ns) and GLY (approx twofold higher, P< 0.01). Uterine, uteroplacental and fetal uptake rates of several AA, particularly the branch chain AA, were lower in H than C animals, producing lower total fetal nitrogen uptake rates (270+/-64 mg N/kg fetus/day H, 696+/-75 mg N/kg fetus/day C, P=0.001) and lower fetal plasma concentrations for the branch chain AA. Most fetal [AA], however, remained at control values, which could occur by relative increase in fetal amino-acid production and/or decrease in utilization, but not by increased uteroplacental transport rates.
Authors:
P J Thureen; J F Padbury; W W Hay
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Placenta     Volume:  22     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    2001 Feb-Mar
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-05-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  162-70     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Harcourt Publishers Ltd.
Affiliation:
The Perinatal Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA. patti.thureen@uchsc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acids / blood,  deficiency*,  metabolism*
Animals
Biological Transport
Female
Fetus / metabolism
Gestational Age
Hyperglycemia / metabolism
Hyperinsulinism / metabolism
Nitrogen / metabolism
Placenta / metabolism*
Pregnancy
Sheep
Time Factors
Grant Support
ID/Acronym/Agency:
DK52138/DK/NIDDK NIH HHS; HD01061/HD/NICHD NIH HHS; HD20761/HD/NICHD NIH HHS; HD28794/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Placental transport and metabolism of amino acids.
Next Document:  A multiple infusion start time (MIST) protocol for stable isotope studies of fetal blood.