| The effect of maternal hypercholesterolemia on the placenta and fetal arteries in rabbits. | |
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MedLine Citation:
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PMID: 22159432 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: To investigate the degree of placental permeability in dyslipidemic rabbits and the consequent vascular dysfunction in fetuses of female rabbits with high lipoprotein levels. METHODS: Fifteen adult females New Zealand White rabbits were divided into two groups. Group 1(n=5) - hypercholesterolemic diet with 0.5% cholesterol, and Group 2 (n=10) - control. On day 30, the levels of plasma lipoproteins and triglycerides were analyzed in the mothers, and the presence of collagen was analyzed in the placenta as well as in fetal coronary and aorta. Statistical analyses used the Student's t and the Mann-Whitney tests. RESULTS: Lipoprotein levels were significantly different (p=0.02 to p<0.001) in experimental and control groups. In the hypercholesterolemic group, total cholesterol levels were in average 793mg/dl; triglycerides were in average 257mg/dl; HDL-C was 48mg/dl, and LDL-C was in average 692mg/dl. The amount of collagen per micrometers square (mµ²) in samples from hypercholesterolemic animals was significantly higher than in the control group. CONCLUSIONS: The study confirmed placental permeability to lipoproteins, shown by increased amounts of collagen in fetal tissues. This alteration results in increased susceptibility to atherosclerosis in adult life, representing a risk factor for the early development of disease, which may appear even in the prenatal period. |
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Authors:
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Elemara Frantz; Honório Sampaio Menezes; Kellyn Cristine Lange; Milena Pacheco Abegg; Cora Albrecht Correa; Leoni Zangalli; Jefferson Luís Vieira; Cláudio Galeano Zettler |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia Volume: 27 ISSN: 1678-2674 ISO Abbreviation: Acta Cir Bras Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9103983 Medline TA: Acta Cir Bras Country: Brazil |
Other Details:
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Languages: eng Pagination: 7-12 Citation Subset: IM |
Affiliation:
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FUC, Porto Alegre, RS, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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