Document Detail

The effect of mannitol on oxygenation and creatine kinase MB release in patients undergoing multivessel off-pump coronary artery bypass surgery.
MedLine Citation:
PMID:  17320568     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Despite avoiding cardiopulmonary bypass, off-pump coronary artery bypass surgery is associated with reduction in PaO2 and postoperative respiratory compliance. Also, transient interruption of coronary flow is necessary during distal anastomoses and may impose ischemia-reperfusion myocardial injury. Mannitol is an osmotic diuretic with free radical scavenging properties, and we have evaluated the effects of mannitol on oxygenation and cardiac enzyme release in patients undergoing multivessel off-pump bypass surgery in a prospective, randomized, controlled, double-blind trial. METHODS: Fifty patients were randomly allocated to receive either 20% mannitol 0.5 g/kg (n = 25) or normal saline 2.5 mL/kg (n = 25) during Y-graft construction. Pulmonary variables and serum sodium concentrations were measured 15 minutes after induction of anesthesia and sternum closure. Creatine kinase MB was measured before and after the operation. Intraoperative and postoperative fluid input and output, time to extubation, and intraoperative hemodynamic variables were also recorded. RESULTS: PaO2 after sternum closure was significantly higher in the mannitol group, with faster time to extubation and shorter length of stay in the intensive care unit. Intraoperative urine output was significantly greater in the mannitol group, without significant differences in fluid input, serum sodium concentration, and hemodynamic variables. Number of patients with a creatine kinase MB level more than 3 times the upper limit of normal was significantly higher in the control group. CONCLUSION: Mannitol could be safely used without adverse side effects in patients undergoing multivessel off-pump bypass surgery with beneficial effects in terms of preserving oxygenation, earlier extubation, and fewer patients with significant creatine kinase MB elevation.
Jae Kwang Shim; Seung Ho Choi; Young Jun Oh; Chang Seok Kim; Kyung Jong Yoo; Young Lan Kwak
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  133     ISSN:  1097-685X     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-26     Completed Date:  2007-03-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  704-9     Citation Subset:  AIM; IM    
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea.
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MeSH Terms
Blood Gas Analysis
Coronary Angiography
Coronary Artery Bypass, Off-Pump / adverse effects,  methods*
Coronary Stenosis / mortality,  radiography,  surgery*
Creatine Kinase, MB Form / drug effects*,  metabolism
Double-Blind Method
Follow-Up Studies
Infusions, Intravenous
Intraoperative Care
Mannitol / therapeutic use*
Middle Aged
Oxygen Consumption / drug effects*
Postoperative Complications / prevention & control
Preoperative Care
Prospective Studies
Pulmonary Gas Exchange
Reference Values
Risk Assessment
Survival Rate
Treatment Outcome
Reg. No./Substance:
69-65-8/Mannitol; EC Kinase, MB Form

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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