| The effect of maneb, zineb, and ethylenethiourea on the humoral activity of the pituitary-thyroid axis in rat. | |
| | |
MedLine Citation:
|
PMID: 3938269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Ethylenebisdithiocarbamates (EBDCs) maneb and zineb are widely used fungicides the final metabolite of which is ethylenethiourea (ETU). EBDCs distort the humoral activity of the thyroid gland, and ETU is especially active in this respect. Male Wistar rats were exposed either to exogenous (100 ng i.p.) or endogenous (+4 degrees C) TRH stimulation. ETU (100-500 mg/kg i.p.) caused no changes in serum TSH levels whereas zineb (70-500 mg/kg i.p.) significantly decreased the bursts induced by cold or exogenous TRH. Maneb (20-200 mg/kg i.p.) significantly decreased the cold-induced TSH response while it had no effect on the TRH-stimulated TSH secretion. None of the agents caused significant changes in serum T3 or T4 levels. It seems that maneb, and zineb, but not ETU, inhibit rat TSH secretion through an action on the endogenous TRH at the hypothalamic or pituitary level. The mechanism behind this action may be the inhibition of dopamine-beta-hydroxylase. |
| | |
Authors:
|
A Laisi; R Tuominen; P Männistö; K Savolainen; J Mattila |
Related Documents
:
|
1541929 - Requirement of oestrogens for the sensitivity of prolactin cells to vasoactive intestin... 7363859 - Development of tolerance to the prolactin-releasing action of morphine and its modulati... 12165809 - Preproglucagon derived peptides and thyrotropin (tsh) secretion in the rat: robust and ... 7651909 - Gonadotropin-releasing hormone influences the release of prolactin and growth hormone f... 6496669 - Excess in vitro prolactin secretion by pituitary cells from ovariectomized old rats. 7532779 - Galanin counteracts the inhibitory effects of glucocorticoids on growth hormone secreti... 7792719 - Effects of the sigma receptor ligand sr 31742a on neurotensin biosynthesis in rat basal... 12621529 - Chronic blockade of neuronal nitric oxide synthase does not affect long-term control of... 1708699 - Inhibition of rat yolk sac tumour growth in vivo by a monoclonal antibody to the retrov... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement Volume: 8 ISSN: 0171-9750 ISO Abbreviation: Arch. Toxicol. Suppl. Publication Date: 1985 |
Date Detail:
|
Created Date: 1986-04-10 Completed Date: 1986-04-10 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 7802567 Medline TA: Arch Toxicol Suppl Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 253-8 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cold Temperature Depression, Chemical Dopamine beta-Hydroxylase / antagonists & inhibitors Ethylenethiourea / pharmacology* Imidazoles / pharmacology* Male Maneb / pharmacology* Pituitary Gland, Anterior / drug effects*, secretion Rats Rats, Inbred Strains Secretory Rate / drug effects Thiocarbamates / pharmacology* Thyroid Gland / drug effects*, secretion Thyrotropin / secretion* Thyrotropin-Releasing Hormone / pharmacology Thyroxine / secretion* Triiodothyronine / secretion* Zineb / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Imidazoles; 0/Thiocarbamates; 12122-67-7/Zineb; 12427-38-2/Maneb; 24305-27-9/Thyrotropin-Releasing Hormone; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin; 96-45-7/Ethylenethiourea; EC 1.14.17.1/Dopamine beta-Hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: p-Cresol formation by cell-free extracts of Clostridium difficile.
Next Document: Free and bound testosterone in male heroin addicts.