Document Detail

The effect of macrophage depletion on delayed xenograft rejection: studies in the guinea pig-to-C6-deficient rat heart transplantation model.
MedLine Citation:
PMID:  10704069     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to investigate the effect of macrophage depletion, using liposome-encapsulated dichloromethylene diphosphonate (Lip-Cl2MDP), on delayed xenograft rejection (DXR) in the guinea pig-to-C6-deficient rat heart transplantation model. In this model, hyperacute rejection does not occur, but, in untreated recipients, xenografts are still destroyed by DXR within 1-2 days. Graft survival was 68 +/- 8.4 h in splenectomized control rats, 77 +/- 16.3 h with Lip-Cl2MDP alone, 99 +/- 10.4 h with deoxysperguarlin (DSG; P < 0.01 vs. controls), and 127 +/- 19.4 h with Lip-Cl2MDP plus DSG (P < 0.01 vs. DSG alone). Treatment with DSG alone or in combination with Lip-Cl2MDP resulted in significant reductions in serum IgM levels at rejection. Immunohistological studies showed that Lip-Cl2MDP alone or in combination with DSG reduced infiltration of grafts by both EDI + and ED2 + macrophages. These experiments support the concept that macrophages play an important role in DXR and suggest that strategies targeting macrophages may be useful in controlling DXR.
G Wu; O Korsgren; N van Rooijen; L Wennberg; A Tibell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Xenotransplantation     Volume:  6     ISSN:  0908-665X     ISO Abbreviation:  Xenotransplantation     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-03-21     Completed Date:  2000-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9438793     Medline TA:  Xenotransplantation     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  262-70     Citation Subset:  IM    
Department of Transplantation Surgery, Huddinge Hospital, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Complement C6 / deficiency*
Diphosphonates / pharmacology*
Graft Rejection / immunology,  prevention & control*
Graft Survival / drug effects
Guanidines / pharmacology
Guinea Pigs
Heart Transplantation / immunology*
Immunosuppression / methods*
Immunosuppressive Agents / pharmacology
Macrophages / drug effects*,  immunology
Methane / pharmacology*
Rats, Mutant Strains
Transplantation, Heterologous / immunology*
Reg. No./Substance:
0/Complement C6; 0/Diphosphonates; 0/Guanidines; 0/Immunosuppressive Agents; 0/LE-Cl2MDP; 74-82-8/Methane; 84937-45-1/gusperimus

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