| The effect of macrophage depletion on delayed xenograft rejection: studies in the guinea pig-to-C6-deficient rat heart transplantation model. | |
MedLine Citation:
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PMID: 10704069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to investigate the effect of macrophage depletion, using liposome-encapsulated dichloromethylene diphosphonate (Lip-Cl2MDP), on delayed xenograft rejection (DXR) in the guinea pig-to-C6-deficient rat heart transplantation model. In this model, hyperacute rejection does not occur, but, in untreated recipients, xenografts are still destroyed by DXR within 1-2 days. Graft survival was 68 +/- 8.4 h in splenectomized control rats, 77 +/- 16.3 h with Lip-Cl2MDP alone, 99 +/- 10.4 h with deoxysperguarlin (DSG; P < 0.01 vs. controls), and 127 +/- 19.4 h with Lip-Cl2MDP plus DSG (P < 0.01 vs. DSG alone). Treatment with DSG alone or in combination with Lip-Cl2MDP resulted in significant reductions in serum IgM levels at rejection. Immunohistological studies showed that Lip-Cl2MDP alone or in combination with DSG reduced infiltration of grafts by both EDI + and ED2 + macrophages. These experiments support the concept that macrophages play an important role in DXR and suggest that strategies targeting macrophages may be useful in controlling DXR. |
Authors:
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G Wu; O Korsgren; N van Rooijen; L Wennberg; A Tibell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Xenotransplantation Volume: 6 ISSN: 0908-665X ISO Abbreviation: Xenotransplantation Publication Date: 1999 Nov |
Date Detail:
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Created Date: 2000-03-21 Completed Date: 2000-03-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9438793 Medline TA: Xenotransplantation Country: DENMARK |
Other Details:
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Languages: eng Pagination: 262-70 Citation Subset: IM |
Affiliation:
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Department of Transplantation Surgery, Huddinge Hospital, Karolinska Institute, Stockholm, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Complement C6 / deficiency* Diphosphonates / pharmacology* Graft Rejection / immunology, prevention & control* Graft Survival / drug effects Guanidines / pharmacology Guinea Pigs Heart Transplantation / immunology* Immunosuppression / methods* Immunosuppressive Agents / pharmacology Macrophages / drug effects*, immunology Methane / pharmacology* Rats Rats, Mutant Strains Transplantation, Heterologous / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Complement C6; 0/Diphosphonates; 0/Guanidines; 0/Immunosuppressive Agents; 0/LE-Cl2MDP; 74-82-8/Methane; 84937-45-1/gusperimus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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