| The effect of luminal content and rate of occlusion on the interpretation of colonic manometry. | |
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MedLine Citation:
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PMID: 23228077 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background Manometry is commonly used for diagnosis of esophageal and anorectal motility disorders. In the colon, manometry is a useful tool, but clinical application remains uncertain. This uncertainty is partly based on the belief that manometry cannot reliably detect non-occluding colonic contractions and, therefore, cannot identify reliable markers of dysmotility. This study tests the ability of manometry to record pressure signals in response to non-lumen-occluding changes in diameter, at different rates of wall movement and with content of different viscosities. Methods A numerical model was built to investigate pressure changes caused by localized, non-lumen-occluding reductions in diameter, similar to those caused by contraction of the gut wall. A mechanical model, consisting of a sealed pressure vessel which could produce localized reductions in luminal diameter, was used to validate the model using luminal segments formed from; (i) natural latex; and (ii) sections of rabbit proximal colon. Fluids with viscosities ranging from 1 to 6800 mPa s(-1) and luminal contraction rates over the range 5-20 mmHg s(-1) were studied. Key Results Manometry recorded non-occluding reductions in diameter, provided that they occurred with sufficiently viscous content. The measured signal was linearly dependent on the rate of reduction in luminal diameter and also increased with increasing viscosity of content (R(2) = 0.62 and 0.96 for 880 and 1760 mPa s(-1) , respectively). Conclusions & Inferences Manometry reliably registers non-occluding contractions in the presence of viscous content, and is therefore a viable tool for measuring colonic motility. Interpretation of colonic manometric data, and definitions based on manometric results, must consider the viscosity of luminal content. |
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Authors:
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J W Arkwright; A Dickson; S A Maunder; N G Blenman; J Lim; G O'Grady; R Archer; M Costa; N J Spencer; S Brookes; A Pullan; P G Dinning |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-10 |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: - ISSN: 1365-2982 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Blackwell Publishing Ltd. |
Affiliation:
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CSIRO Materials Science and Engineering, Lindfield, NSW, Australia Science and Engineering Faculty, Queensland University of Technology, Brisbane, QLD, Australia Bioengineering Institute, University of Auckland, New Zealand Dept of Surgery and Bioengineering Institute, University of Auckland, New Zealand Department of Engineering Science, University of Auckland, New Zealand Department of Human Physiology, Flinders University, Bedford Park, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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