Document Detail


The effect of low molecular weight heparin (dalteparin) on duration and initiation of labour.
MedLine Citation:
PMID:  19949968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has recently been reported that women treated with low molecular weight heparin (LMWH) during pregnancy had 3 h shorter duration of delivery. The aim of the present study was to evaluate whether LMWH (dalteparin) affects labour. From January 1996 to December 2005, 217 consecutive pregnancies, out of 34 216 newborn (prevalence 0.6%) that were given thromboprophylaxis with dalteparin (usually 5,000 IU once daily). These 217 consecutive pregnancies were compared to an unselected control group (n = 1,499) of gravidae. Main outcome was time in first and second stage of labour and gestational age at delivery. Among nulliparous women, there were significantly fewer women with prolonged first stage of labour as compared to controls (4.1% vs. 8.5%, P = 0.047). In addition, the duration of first stage of labour was 1 h shorter among those treated with LMWH (5.2 vs. 6.2 h, P = 0.06). There were no such differences among parous women. The risk of prematurity, profuse blood loss, and postpartum anaemia was almost doubled among those treated with LMWH (11.5% vs. 5.9%, P = 0.002, 10.6% vs. 5.9%, P < 0.001, and 12.9% vs. 8.7%, P = 0.048, respectively). Treatment with a prophylactic dose of LMWH (dalteparin) during pregnancy was related to fewer women with prolonged first stage of labour, but also to an increased risk of prematurity and blood loss complications.
Authors:
Nazim Isma; Peter J Svensson; Bengt Lindblad; Pelle G Lindqvist
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  30     ISSN:  1573-742X     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  149-53     Citation Subset:  IM    
Affiliation:
Department of Clinical Chemistry, Centre for Thrombosis and Haemostasis, Malmö University Hospital, Lund University, Malmö, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticoagulants / adverse effects,  therapeutic use*
Case-Control Studies
Chi-Square Distribution
Dalteparin / adverse effects,  therapeutic use*
Female
Gestational Age
Humans
Labor Onset / drug effects*
Labor Stage, First / drug effects*
Parity
Postpartum Hemorrhage / chemically induced
Pregnancy
Pregnancy Complications, Hematologic / blood,  prevention & control*
Premature Birth / chemically induced
Retrospective Studies
Risk Assessment
Risk Factors
Sweden
Time Factors
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Dalteparin

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