Document Detail

The effect of low-molecular weight dextran on erythrocyte aggregation in normal and preeclamptic pregnancy.
MedLine Citation:
PMID:  10831064     Owner:  NLM     Status:  MEDLINE    
Erythrocyte aggregation was determined by a novel method enabling the quantification of the aggregation process in whole blood. Blood samples of 47 healthy pregnant women and 39 preeclamptic patients were examined. Subjects within each group were matched for the gestational age. It was found that RBC aggregation increases with the gestational age in healthy pregnancy and further increases in preeclampsia. Addition of low-molecular weight dextran (MW = 9300) to blood samples of both healthy pregnant women and preeclamptic patients reduces RBC aggregation in a concentration-dependent manner. The obtained results indicate alterations in plasma composition as the primary factor for the increased RBC aggregation in both normal and pathological pregnancy. It is suggested that adsorption of low-molecular weight dextran on the RBC membrane reduces the surface concentration of plasma bridging molecules thereby reducing RBC aggregation toward normal.
A Pribush; D Mankuta; H J Meiselman; D Meyerstein; T Silberstein; M Katz; N Meyerstein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  22     ISSN:  1386-0291     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  2000  
Date Detail:
Created Date:  2000-09-29     Completed Date:  2000-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  143-52     Citation Subset:  IM    
Physiology Department, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
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MeSH Terms
Dextrans / chemistry,  pharmacology*
Erythrocyte Aggregation / drug effects*
Fibrinogen / analysis
Molecular Weight
Pre-Eclampsia / blood*,  complications
Pregnancy / blood*
Pregnancy Complications, Hematologic / blood,  etiology
Thrombophilia / blood,  etiology
Reg. No./Substance:
9001-32-5/Fibrinogen; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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