Document Detail

The effect of low and moderate fat intakes on the postprandial lipaemic and hormonal responses in healthy volunteers.
MedLine Citation:
PMID:  10341672     Owner:  NLM     Status:  MEDLINE    
Present literature indicates that whereas an acute fat intake of 5 g does not elicit a postprandial triacylglycerolaemic response, 20 g of fat does. Since 67% of fat intake occasions involve fat doses of less than 20 g, the present study examined the effect of a relatively low-fat (LF) meal (0.2 g/kg body weight; mean 14 g) on postprandial triacylglycerol (TAG) metabolism, compared with a high-fat (HF) meal (0.6 g/kg body weight; mean 43 g), a fat dose which is more typical of laboratory studies. Plasma- and chylomicron-TAG concentrations increased significantly (P < or = 0.001) following both meals, and the increase was significantly (P < or = 0.02) greater after the HF meal. The postprandial areas under the curves and maximal postprandial TAG concentrations for plasma- and chylomicron-TAG were significantly higher following the HF meal (P < or = 0.05). Postprandial plasma insulin and gastric inhibitory polypeptide concentrations increased significantly (P < or = 0.001) after each meal, but there was no difference between the two meals. These data show that modest amounts of fat in a meal will elicit a measurable postprandial TAG response. Since postprandial lipaemia affects the composition and concentration of the TAG- and cholesterol-rich lipoproteins, controlling dietary TAG supply may influence the metabolic fate of these lipoproteins.
F Shishehbor; H M Roche; M J Gibney
Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  81     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-05-27     Completed Date:  1999-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  25-30     Citation Subset:  IM    
Department of Clinical Medicine, Trinity Centre for Health Sciences, St James's Hospital, Dublin, Republic of Ireland.
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MeSH Terms
Analysis of Variance
Area Under Curve
Chylomicrons / metabolism
Dietary Fats / administration & dosage*,  metabolism
Gastric Inhibitory Polypeptide / blood*
Insulin / blood*
Postprandial Period*
Regression Analysis
Time Factors
Triglycerides / blood*
Reg. No./Substance:
0/Chylomicrons; 0/Dietary Fats; 0/Triglycerides; 11061-68-0/Insulin; 59392-49-3/Gastric Inhibitory Polypeptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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