| The effect of low levels of dietary cobalt on the chemiluminescence response of polymorphonuclear leukocytes of goats. | |
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MedLine Citation:
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PMID: 19679325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty ten-week-old newly weaned male Batinah goats were randomly assigned to a control (n=10) and a treated (n=10) group and were fed a diet containing 0.1mg/kg DM cobalt (Co). Goats in the treated group received bi-monthly subcutaneous injections of 2000 microg of hydroxycobalamin. The phagocytic function of the polymorphonuclear leukocytes (PMN) were tested using a luminol-dependent chemiluminescence assay with opsonized zymosan as the phagocytic target. One month after the onset of the experiment PMN from the control group exhibited a significantly (p<0.05) lower CL response, which continued for the second month. The results of the present study demonstrated that low levels of dietary cobalt leads to an early impairment of phagocytic function. This may at least in part, be an explanation as to why at the field level in Oman young goats fed diets containing low levels of Co appear to be more susceptible to infections. |
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Authors:
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Eugene H Johnson; Khalid Al-Habsi; Rashid Al-Busaidy; Samera Kasim Khalaf |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2009-08-12 |
Journal Detail:
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Title: Research in veterinary science Volume: 88 ISSN: 1532-2661 ISO Abbreviation: Res. Vet. Sci. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-19 Completed Date: 2010-03-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401300 Medline TA: Res Vet Sci Country: England |
Other Details:
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Languages: eng Pagination: 61-3 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Animal and Veterinary Sciences, College of Agricultural and Marine Sciences, Sultan Qaboos University, Al-Khod 123, Oman. ejohnson@squ.edu.om |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemiluminescent Measurements Cobalt / pharmacology* Dietary Supplements* Goats / blood, immunology* Hydroxocobalamin / pharmacology Male Neutrophils / drug effects*, physiology Phagocytosis / drug effects, physiology Vitamin B 12 / blood Vitamin B Complex / pharmacology Zymosan / metabolism |
| Chemical | |
Reg. No./Substance:
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12001-76-2/Vitamin B Complex; 13422-51-0/Hydroxocobalamin; 68-19-9/Vitamin B 12; 7440-48-4/Cobalt; 9010-72-4/Zymosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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