Document Detail


The effect of low-level ozone concentrations on the serum levels of immunoglobulins, alpha-1-antitrypsin and transferrin and on the activation of peripheral lymphocytes.
MedLine Citation:
PMID:  6969275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Long-term exposure (2--9 years) to ozone levels exceeding the Czechoslovak value of mean maximum allowable concentration (0.1 mg . m-3) turned out to induce changes in the exposed persons which can be characterized as initial immune disorders. Higher levels of IgG, IgA, IgM, alpha-1-antitrypsin and transferrin detected in comparison to the reference value in the group of ozone-exposed persons and significantly increased alpha-1-antitrypsin and transferrin levels in comparison to the control group of ore miners can be interpreted as a result of changed adaptation mechanisms in the organism. Analysis of the distribution pattern of the frequency of IgA and IgG changes exceeding the standard deviation shows that the group of ozone-exposed subjects exhibits a higher frequency of these changes than the control group of ore miners. However, the concurrently compared relative numbers of increases and decreases in both groups seem to indicate a considerable interindividual variability in the indicators studied.
Authors:
L Ulrich; E Malík; M Hurbánková; R Kemka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hygiene, epidemiology, microbiology, and immunology     Volume:  24     ISSN:  0022-1732     ISO Abbreviation:  J Hyg Epidemiol Microbiol Immunol     Publication Date:  1980  
Date Detail:
Created Date:  1981-02-19     Completed Date:  1981-02-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985116R     Medline TA:  J Hyg Epidemiol Microbiol Immunol     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  303-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Environmental Exposure
Humans
Immunoglobulin A / metabolism
Immunoglobulin D / metabolism
Immunoglobulin G / metabolism
Immunoglobulin M / metabolism
Immunoglobulins / metabolism*
Lymphocyte Activation / drug effects
Ozone / pharmacology*
Transferrin / metabolism*
alpha 1-Antitrypsin / metabolism*
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin D; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Immunoglobulins; 0/alpha 1-Antitrypsin; 10028-15-6/Ozone; 11096-37-0/Transferrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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