Document Detail

The effect of a low-glycemic diet vs a standard diet on blood glucose levels and macronutrient intake in children with type 1 diabetes.
MedLine Citation:
PMID:  19167958     Owner:  NLM     Status:  MEDLINE    
A low-glycemic index (GI) diet may lower postprandial hyperglycemia and decrease the risk for postabsorptive hypoglycemia in people with type 1 diabetes. However, insufficient evidence exists on the efficacy of a low-GI diet to support practice recommendations. The goal of this study was to examine the blood glucose response to and the macronutrient composition of low-GI meals vs usual meals consumed ad libitum at home in children with type 1 diabetes. A within-subject, crossover design was employed. Twenty-three participants were recruited between June and August 2006. Participants wore a continuous blood glucose monitoring system and completed diet diaries on 2 days. On 1 day, participants consumed their usual meal; on another day, participants consumed low-GI meals ad libidum. Order of the 2 days was counterbalanced. The mean GI was 34+/-6 for the low-GI day and 57+/-6 for the usual meal day (P<0.0001). During the low-GI day, mean daytime blood glucose values (125+/-28 mg/dL [6.9+/-1.5 nmol/L] vs 185+/-58 mg/dL [10.3+/-3.2 nmol/L], P<0.001), blood glucose area above 180 mg/dL (4,486+/-6,138 vs 26,707+/-25,038, P<0.006), and high blood glucose index (5.1+/-5.1 vs 13.6+/-7.6, P<0.001) were lower compared to the usual mean day. During the low-GI day, subjects consumed more fiber (24.5+/-12.3 g vs 14.5+/-6.1 g, P<0.007) and less fat (45.7+/-12.2 g vs 76.8+/-32.4 g, P<0.005); however, there were no differences in energy, carbohydrate, or protein intake. In this pilot study, a low-GI diet was associated with improved diet quality and a reduction in hyperglycemia.
Alisha J Rovner; Tonja R Nansel; Lauren Gellar
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Journal of the American Dietetic Association     Volume:  109     ISSN:  0002-8223     ISO Abbreviation:  J Am Diet Assoc     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-26     Completed Date:  2009-03-16     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  7503061     Medline TA:  J Am Diet Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  303-7     Citation Subset:  AIM; IM    
Division of Epidemiology, Statistics and Prevention Research, NICHD, NIH, DHHS, Bethesda, MD 20892-7510, USA.
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MeSH Terms
Area Under Curve
Blood Glucose / analysis,  metabolism*
Blood Glucose Self-Monitoring
Cross-Over Studies
Diabetes Mellitus, Type 1 / blood*,  diet therapy*
Dietary Carbohydrates / administration & dosage*,  classification,  metabolism
Dietary Fats / administration & dosage,  metabolism
Dietary Fiber / administration & dosage,  metabolism
Dietary Proteins / administration & dosage,  metabolism
Energy Intake
Food / classification
Glycemic Index*
Hemoglobin A, Glycosylated / analysis
Hyperglycemia / blood,  prevention & control*
Insulin / therapeutic use
Pilot Projects
Postprandial Period
Grant Support
Z01 HD008805-01/HD/NICHD NIH HHS
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 0/Hemoglobin A, Glycosylated; 0/Insulin

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