Document Detail

The effect of low-dose supplementation with n-3 polyunsaturated fatty acids on some risk markers of coronary heart disease.
MedLine Citation:
PMID:  8378746     Owner:  NLM     Status:  MEDLINE    
Epidemiological data have suggested that a low dose of dietary n-3 polyunsaturated fatty acids from seafood may protect against coronary heart disease. We studied the effect of supplementation with a low dose of very long-chain n-3 fatty acids (0.65 g day-1) on plasma lipids, haemostasis, and neutrophil aggregation. Twenty-four healthy subjects were randomized to supplementation with very long-chain n-3 fatty acids or a control oil for 8 weeks. Laboratory analyses were done twice before and twice at the end of the supplementation period. The supplement with n-3 polyunsaturated fatty acid did not significantly affect plasma lipids or plasma levels of fibrinogen, factor VII, plasminogen activator inhibitor, whole blood aggregation or aggregability of neutrophil leukocytes. Therefore, the potential beneficial effect of very long-chain n-3 fatty acids in coronary heart disease is likely to be mediated through other mechanisms.
H H Lervang; E B Schmidt; J Møller; N Svaneborg; K Varming; P H Madsen; J Dyerberg
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  53     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-10-20     Completed Date:  1993-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  417-23     Citation Subset:  IM    
Department of Medicine, Aalborg Hospital, Denmark.
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MeSH Terms
Coronary Disease / prevention & control*
Factor VII / analysis
Fatty Acids, Omega-3 / pharmacology*
Lipids / blood
Middle Aged
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Lipids; 9001-25-6/Factor VII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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